Introduce Extrauterine Growth Status And Related Factors In Very Low Birth Weight Infants

Objective: To understand the extrauterine growth (weight, height, headcircumference) and nutritional status of very low birth weight infantsduring hospitalization and evaluate the extrauterine growth retardation inthe incidence and related risk factors.Method: A observed and analyzed retrospectively is chosen forhospitalized premature infants from April2013to October2013in MedicalUniversity Of Chongqing Affiliated Children’s hospital NICU. Inclusioncriteria: birth weight <1500g, age<1d. Exclusion criteria: hospital stays≤2w,with congenital abnormalities, endocrine and metabolic diseases whichhave a bad impact on individual growth and development, abandon therapyor die before discharge. The selected30very low birth weight infants wereweekly measured in length and head circumference by a follow-up researchmethods. Using the Fenton premature infants’ growth curve, evaluate thegrowth status of intrauterine and extrauterine and divide them into groups.Analyse the general clinical conditions (including gender, gestational age,birth weight, birth length, birth head circumference, hospitalization time, discharge gestational age, discharge weight, discharge length, dischargehead circumference),growth status (including the growth speed of weight,height, head circumference, minimum weight age, the age of birth weightrecovery), nutritional status (including the first time of initiation parenteralnutrition, duration of parenteral nutrition, the first time of initiation enteralnutrition, the age of full enteral nutrition, fasting days) and in-hospitaldisease state (including respiratory distress syndrome, sepsis, patent ductusarteriosus, necrotizing enterocolitis, asphyxia, apnea, respiratory failure,feeding intolerance, cholestasis, severe anemia, respiratory support).Chi-square test is chosen for count data, T-test for normal distributionmeasurement data comparison and rank sum for non-normal distributionmeasurement data.Result:30cases of VLBWI conformed to the inclusion criteria duringApril2013to October2013(male14cases, female16cases), evaluated bybirth weight,length and head circumference respectively,the IUGRoccurred in40%,36.7%and56.7%, and the EUGR in80%,33.3%and56.7%; Only8cases (26.7%) reached the normal fetal growth rate in fetalweight during hospitalization; The incidence of EUGR when discharge wassignificantly higher in the IUGR infants than that of non IUGR; Theincidence of IUGR and EUGR increased with the increasing of gestationalage; The incidence rate of EUGR decreased with the increasing of birthweight; The weight growth speed of the IUGR VLBWI was faster than the non IUGR, while the weight growth speed has no statistically significant inthe incidence of EUGR when discharged; The common risk factors ofEUGR were gestational age, birth weight, gestational age,IUGR-W,IUGR-L and IUGR-H when evaluated by weight, height, headcircumference, in addition, evaluated by weight,polyembryony, firstenteral nutrition age were risk factors, evaluated by length, ICP was riskfactor, evaluated by head circumference, discharge head circumference,intrauterine distress, sepsis were statistically difference.Conclusion:(1)The incidence of IUGR and EUGR in VLBWI is high；Weight, length, head circumference should be included in the referenceindex of growth curve at the same time, but there is no unified growthcurve which applicable to the VLBWI in our country currently;(2)Theincidence of EUGR when discharge was significantly higher in the IUGRinfants than that of non IUGR;(3) Most VLBWI can’t reache the normalfetal growth rate in fetal weight during hospitalization;(4) The weightgrowth speed of the IUGR VLBWI was faster than the non IUGR, whilethe weight growth speed has no statistically significant;(5) Disease statushad no significant influence on the EUGR of VLBWI duringhospitalization.