One Year Following Study On Alternative Bladder Irrigation Treatment For Bladder Cancer With Pirarubicin And Mannatide

Objective: The bladder irrigation has been widely used in clinical practice forprevention of postoperative recurrence of non-muscle-invasive bladder cancer. Thismethod has a positive effect on preventing postoperative recurrence ofnon-muscle-invasive bladder cancer. However, the prognosis has not yet reached thedesired requirements. This study intends to explore the clinical efficacy and safety ofalternative bladder irrigation of pirarubicin (THP) and mannatide for prevention ofpostoperative recurrence of non-muscle-invasive bladder cancer, providing theevidence-based basis for choosing clinical approaches of bladder irrigation.Methods:65cases of patients with non-invasive bladder cancer were admittedand given surgery in our department. They were divided into control group andtreatment group.31patients in control group included29males and five females,with the median age of56years old. Wherein, single tumor occurred in25cases andmultiple tumors in six cases. They were given bladder irrigation of40mg THP onceevery week for eight times during the twice month, followed by irrigation once everymonth for11times during one year.34patients in the treatment group included27males and four females, The median age was57years. Wherein, single tumoroccurred in26cases and multiple tumors in eight cases. They were given alternativebladder irrigation of40mg THP and40mg mannatide once every week for eighttimes during the twice month, followed by irrigation once every month for11timesduring one year. During the follow-up, patients were required for periodic review ofcystoscopy, blood routine examination, and liver and kidney functions. Thepostoperative recurrence rates and adverse reactions were observed in two groups.The follow-up was set to be one year, which was finished at the end of treatment andobservation.Results:65patients were all followed up. The general conditions includinggender, age, clinical stage, histological classification and tumor characteristics wereanalyzed between two groups by related statistical methods, no significant differencs between them(P>0.05). For adverse reactions, the incidence of flu-like symptoms inthe treatment group was higher than that control group(P<0.05); The incidence ratesof other adverse reactions in the treatment group were all lower than that in controlgroup, and no significant differences (P>0.05). The recurrence rate was3.225%inthe treatment group and23.52%in the control group; the difference between themwas statistically significant (P<0.05).Conclusion: Alternative bladder irrigation of THP and mannatide caneffectively reduce the postoperative recurrence rate of non-muscle-invasive bladdercancer, with a high safety, improved patient’s quality of life and good clinicaltolerance, which is worthy of further research and clinical promotion.