Diagnostic Value Of Fibroscan For Chronic Hepatitis B With Steatosis

Objective:To investigate the diagnostic value of Fibroscan for chronic hepatitis B with steatosis.Method:Eighty nine patients with chronic hepatitis B and steatosis in our hospital were included in the study.One hundred and eleven patients with chronic hepatitis B were selected to be the matched group.All the two hundred patients underwent liver biopsy and liver stiffness measurement (LSM) by Fibroscan.First, to analyze if steatosis can influence the Fibroscan for stage of S1、S2、S3and S4.Second, with S stage of liver biopsy as the gold standard to draw receiver characteristic operating curve (ROC).The optimal LSM cut-off values were determined by maximizing the sensitivity and specificity.Results:1. LSM for fibrosis of S2、S3、S4between CHB with steatosis and CHB has statistic differences but not for S1.2. For patients of CHB with steatosis, the AUROC were0.964、0.978and0.993for S2、S3、S4.If9.05kPa was used for diagnosis of significant fibrosis (≥S2), the specificity, sensitivity, positive predictive value and negative predictive value were1.000,0.838,1.000,0.656. If12.6kPa was used for diagnosis of severe fibrosis (>S3), the specificity, sensitivity, positive predictive value and negative predictive value were0.955,0.911,0.954,0.913. If17.65kPa was used for diagnosis of cirrhosis (S4), the specificity, sensitivity, positive predictive value and negative predictive value were0.941,1.000,0.840,1.000.