The Role Of APRI And FibroScan In Predicting Liver Fibrosis Progression In Chronic Hepatitis B

Backgrounds/Aims:To compare the prediction and dynamic monitoring efficiency between APRI and Fibro Scan in the progressing of hepatofibrosis in chronic hepatitis B, and to investigate the worth of associated application.Methods:45 adult patients with chronic hepatitis B who were follow-up from January 2008 to December 2012 regularly and performed liver biopsy respectively. Each patient were performed liver biopsy and Fibro Scan before and after therapy,follow-up in two years,and collect the clinical data. Results:A total of 90 cases of liver biopsy suggested that the value of APRI increased significantly(0.37±0.15 vs 0.58±0.38 vs 1.03±1.01 vs 1.54±1.29 vs 1.56±0.77,F=6.75,P<0.001)with the level of liver biopsy increasing(HAI:0,1,2,3,4).Also the result of Fibro Scan increased(5.08±1.15 vs 6.42±1.83 vs 7.75±2.58 vs 10.24±3.05 vs 21.75±4.74,F=34.79,P<0.001).Both of APRI and Fibro Scan has positive correlation with the degree of liver biopsy(rAPRI=0.523,P<0.001;r Fibro Scan=0.623,P<0.001). Before and after treatment,the area under the ROC curve of Fibro Scan value which predicting hepatofibrosis degree is 0.70(95%CI:0.53-0.86,P=0.043), the area under the ROC curve of APRI value is 0.76(95%CI:0.61-0.92,P=0.006).There is no difference between the area under the ROC curve of Fibor Scan and APRI(X2=0.36,P=0.55).The result of univariate analysis of clinical data and hepatofibrosis degree implied ALT and AST level also have clinical meaning in predicting hepatofibrosis degree. Conclusion:Both of APRI and Fibro Scan value suggested CHB hepatofibrosis degree effectively, and in some dgree, they also have dynamic monitoring meaning. In clinic medical work, combine the level of ALT and AST with liver biopsy can assess hepatofibrosis degree comprehensivlier and in favor of monitoring patient’s situation.