Study On The Correlation Between Expression Of Breast Carcinoma Ultrasonographic Features And Molecular Biology Expression And C Reaction Protein

Objective: To investigate the pathological basis of ultrasonographic signs of breast cancer, study the correlation between the expression of molecular biology, C-reactive protein levels and its breast ultrasound imaging so that to improve the diagnosis of breast cancer by ultrasound technology, and to provide reliable information for the imaging and treatment of breast cancer prognosis, and further enhance the value of ultrasonography in clinical diagnosis and treatment of breast cancer.Methods:Randomly selected pathologically confirmed50cases of breast cancer and50cases of healthy subjects from Jan.2012to June2013, divided them into healthy group (A) and breast cancer group (group B). The breast of all the patients have been checked using high frequency ultrasound with the emphasis on tumor morphology, edge, posterior echo, microcalcifications, internal flow and axillary lymph nodes. All subjects were examined for the level of the serum C-reactive protein by enzyme-linked immunosorbent assay (ELISA) and for generic expression of ER, PR and CerbB-2by immunohistochemical staining method, and their relationship with ultrasound imaging was analyzed.Results:Patients with breast cancer was found to have higher serum C-reactive protein levels compared with healthy group and the comparison if statistically significant (P<0.05). The burr and irregular imaging of the patients with breast cancer was found to have a positive correlation with C-reactive protein level, while, the microcalcifications, internal flow and axillary lymph nodes was found not significantly correlated with C-reactive protein levels.. In the group with aspect ratio>1, the positive rates of ER and PR were77.8%and61.1%, respectively, higher than those in the group with aspect ratio<1(P<0.05); In the group with glitch, the positive rates of ER and PR were65.5%and55.2%, respectively, higher than those in the group with no glitch (P<0.05); For the patients with peripheral hyperechoic halo, the positive rates of ER and PR were73.3%and60.0%, respectively, higher than those for the patients with no echo (P<0.05); For the patients with no internal echo, the positive rate of PR was22.2%, lower than that for that patient with internal echo (P<0.05); For the microcalcifications patients, the positive rate of CerbB-2was83.3%, higher than those for the patients with no microcalcifications (P<0.05).Conclusion:(1) The levels of C-reactive protein in the healthy group in significantly less than that in the patients with breast cancer. And the breast ultrasound imaging and C-reactive protein level is correlated.(2) There is a certain relationship between breast cancer ultrasound imaging and molecular biological indicators. The tumor biological characteristics affect the ultrasound imaging of the breast tumors. Ultrasound imaging can provide the basis for breast cancer prognosis and clinical treatment.