The Preparation Technology And Drug Relean Se Mechanism Of Sustained Release Formulation Materials For Common Hypertension Drugs

Hypertension is a common type of cardiovascular disease, which also belongs to "diseases of affluence ". The incidence is increasing year by year. Since endangeringthe vital organs of the human body such as heart, brain and kidney, hypertensionbecomes a serious threat to human health. The non-drug treatment of hypertension ismainly exercise and diet, and other ways of treatment are drugs. At present, theclinical treatment of hypertension can just be controlled its development and difficultto cure, which determines that the general hypertensive patients need long-termmedication. However, long-term medication can lead to an increase in adversereactions and an strength of side effects. Therefore, the study of hypertension drugdelivery formulations attracts more and more attention.In the paper, we ingeniously combine nano-fibroin with slow-release capabilityand micro-fibroin of self-assemble ability on the basis of our team’s preliminarystudies. The sustained release drug formulation materials were prepared bywrapping hypertension drug, drying and tableting. Besides, the ability of sustainedrelease, toxicity and other experiments were studied.First, the materials of SFP/PVA/PEG and SF/C2H5OH/(Captopril) were preparedseparately. Then, the hypertension drug delivery material were prepared by combiningthe two materials under certain conditions. Its macroscopic morphology was observedand the material was characterized by UV, FTIR, and SEM. The results showed that:the quality of drug delivery material was uniform with small differences, and theprepared tablets had a potential slow-release capability (with large holes or gaps).The content of captopril was determined by derivative spectrophotometry at409nm.The standard curve showed good correlation which also was used to study the in vitrorelease of prepared materials/tablets. The results showed that: no matter in simulatedgastric or intestinal fluid, our prepared captopril tablets release more slowly than thecommercial tablets, the tablets after release had a uniform pore size of1μm-10μm.The dynamics was in line with the kinetic equation of sustained-release formulations(Peppas release kinetics), and it was suitable for the development of sustained-releasepreparations. We speculated that the mechanism should be diffusion or the interactionof diffusion and dissolution together. Cytotoxicity test results showed that cells had agood growth; the cytotoxicity ratings of both release liquid and extracts of the material are at0or1which was in a safe range and had no toxicity to cells withbiological material compatibility requirements. Acute systemic toxicity and sub-acutesystemic toxicity studies found that there were no abnormality, from the cage sideobservations, body weight relative growth rate, organ coefficient and grosspathological examination. The results showed its non-toxicity, compliance with thebio-medical devices safety evaluation criteria.The results showed that the prepared sustained release formulation materials ofcommon hypertension drug had a good ability of sustained-release, nontoxic and safeand had a broad application prospects.