Preliminary Clinical Observation Of Shen JIA RONG GAN Pills In Treatment Of Hepatic Fibrosis

Objective: To observe clinical effect of SHEN JIA RONG GAN Pills in treatment ofhepatic fibrosis, provide theoretical and practical basis for the establishment of theoptimization of integrated Chinese and Western medicine in treating hepatic fibrosis,evaluate the effect and safety of SHEN JIA RONG GAN Pills,explore the mechanismof SHEN JIA RONG GAN Pills, and provide theoretical basis for clinical application,and development of new drug..Methods:88cases of liver fibrosis in chronic hepatitis b patients were randomlydivided into treatment and control groups, treatment group was treated with SHENJIA RONG GAN pills3times a day, each time10g; whereas control groups wastreated with dahuang zhechong pill in the control group,2times a day, each time3gfor3months. Serum markers of liver fibrosis, liver function, color Doppler ultrasound,clinical symptoms and signs, and other clinical indicators and blood count, renalfunction, changes of ECG safety indicators were observed respectively, and theclinical efficacy and safety of two groups were compared and evaluated respectively.Results:①Overall comparison of the two groups: remarkable effective24, effective13, invalid4in41patients of treatment groups and total effective rate90.2%, whereasremarkable effective13, effective15, invalid12in40patients of control groups andtotal effective rate70.0%. There is significant differences between the two groupsStatistically (P<0.05), treatment group is better than control group.②Comparison oftwo sets of syndromes: remarkable effective10, effective26, invalid5of treatmentgroups and total effective rate87.8%, whereas remarkable effective9, effective17,invalid14of control groups and total effective rate65.0%. There is significantdifferences between the two groups on syndrome of traditional Chinese medicineStatistically (P<0.05), treatment group is better than control group.③Comparison of two sets of Clinical symptoms and signs of efficacy: In terms of anepithymia,abdominal fullness and distention,and complexion, treatment group and the controlgroup after t tests, p-values were>0.05, explains no significantly difference;whereasIn terms of side rib pain, fatigue weakness, tongue coating, rib under a lump in theabdomen,treatment group and the control group after t tests, p-values were <0.05,explain significantly difference. The treatment group in improving the side rib pain,fatigue weakness, tongue coating, rib under a lump in the abdomen and other clinicalsigns and symptoms is better than the control group.④Two sets of four indicatorsimproving liver function and liver fiber comparison: treatment in liver function (ALT,AST, and GGT, and A/G) improvement, compared with the control group, thedifference has a significant meaning (P<0.05). Explain treatment group in recoveryliver function (ALT, and AST, and GGT, and A/G) aspects is better than the controlgroup; treatment group in serum liver fiber of indicators (HA,PCIII and CIV)improvement,compared to the control group, There is significant differences (P<0.05);In the aspect of LN indicators of improvement, There is significant difference betweenThe treatment group and the control group (P>0.05). Explain the improvement oftreatment group in serum liver fibrosis (HA,PCIII and CIV),is better than the controlgroup,whereas in terms of improving LN, The differences between the two groups ofcurative effect is not significant.⑤Comparison of two sets of color Doppler flowimaging of liver and spleen index improved:Treatment group in the recovery of thesplenic vein and spleen thickness, compared with the control group, the differencewas significant (P <0.05); in the portal vein indicators, compared with the controlgroup, the difference was not significant significance (P>0.05).Explain In thetreatment group, splenic vein and liver recovery thickness are better than the controlgroup.Conclusion: SHEN JIA RONG GAN Pills is effective in preventing hepatic fibrosisof the liver, and putting off the process of liver cirrhosis, the clinical effect isdefinitized, and deserve to further research and clinical application.