| Objective： This topic in Chinese medicine theory as the guide,Combined with the operation mode, In Fu Yang huogu pill combined withcore decompression on rabbit femoral head necrosis observed as the mai nobjective, To observe the effects on coagulation function, to expl ore themechanism of prevention of steroid induced avascular necrosis of thefemoral head.Methods：The45New Zealand adult healthy rabbits were selected asthe object of study, Except blank control group distribution of good, Allrabbits were the remaining2times/week of intramuscular injection o fhydroprednisone acetate per kg7.5mg, The ani mal model of each injectionof penicil lin sodium80000u/,2ti mes a week t o prevent infection. After6weeks of randomly selected1rats in normal group,4rats in model group,Collected the femoral head bone making pathological section, And earlysteroid induced avascular necrosis of the femoral head after modelingsuccess, The model rabbits were randomly divided into4gr oups of rabbits.The experimental group as follows: The blank control group (nor malgroup), The model group (model group), Fu Yang huogu pill group(Chinese medicine group), Core decompression group (combined group),Fu Yang huogu pil l combined with core decompression group (Chinesemedicine and decompression group). Then the nor mal group and modelgroup were fed with normal saline20ml; Chinese medicine group weregiven compound Yang huogu pill (4.8g/kg.d) dissolved in20ml nor malsaline perfusion; Decompression group percutaneous in greater tuberosit ybelow using2mm bit to the femoral internal puncture decompression;Traditional Chinese medicine and decompression group underwent core decompression with the same dosage of Fu Yang huogu pill; After6weeksof treat ment,12hours of fasting, In the early morning blood, Rabbit earvein blood, And detection of coagulation indexes in rabbits before andafter treatment, Comparative analysis. The remaining rabbits were killed.Results：①The treatment of rabbit body weight were lower than thenor mal group, Decompression group weight before treatment is higherthan that after treatment Chi nese medi cine treatment group body weightduring the treatment has also increased, Weight gain is more obvious forthe traditional Chinese medicine combi ned with decompression group；②Observation of tissue and pathology: The normal group had noabnor mal findings, The model group bone Liang Wei small and sparse,Bone marrow fat cell growth, change, There are three sets of(decompression and traditional Chinese medicine and traditional Chinesemedicine and decompression group) lesions compared with hor mone group,Near normal with Chinese traditional medicine and decompression group;③Detection of blood coagulation function: Traditional Chinesemedicine and decompression group and Chinese medi cine group, Theblood coagulation function of two group was significantly lower than themodel group P value <0.01, Analysis of group and decompression groupblank comparison of P>0.05, The most close to the normal level for thetraditional Chinese medicine and decompression group.Conclusion：1、 the experiment proved once again that a large dose ofhor mone can cause the model group appeared avascular necrosis of thefemoral head, In addition to the hemorheology, blood lipid, seru mphosphorus, calcium, plasma NO level, ET-1level and experimental rabbitbody weight and growth effects, Also have an i mpact on blood coagul ationfunction.2、 There is an inevitable link variation in incidence andcoagulation function of SANFH, Fu Yang huogu pill by Huoxue HuayuTongluo, war ming yang and cold make blood circulation increases role,Inhibition of the process of intravascular coagulation, Maintenance ofvascular endothelial cell function and good lipid metabolism, It i sdifficult t o for m the coagulation environment, I t plays an i mportant rolein the avascular necrosis of the femoral head in the prevention andtreatment of the. |
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