Expression And Clinical Significance Of FOXC1and E-cadherin In Nasopharyngeal Carcinoma Tissues

Objective: This work aimed to evaluate the expression of FOXC1and E-cadherin in nasopharyngeal carcinoma tissues and nasopharyngitistissues, to discuss their relevance and the roles in carcinogenesis anddevelopment of nasopharyngeal carcinoma, and to investigate theircorrelation with the clinicopathological features. Methods:Immunohistochemical technique was used to detect the expression ofFOXC1and E-cadherin on tissue microarray slice obtained from98casesof nasopharyngeal carcinoma tissues and32cases of nasopharyngitistissues. Results:(1) Immunoreaction to FOXC1was mainly located innucleus of nasopharyngeal carcinoma cells. The positive expression rateof FOXC1in nasopharyngeal carcinoma tissues (85.3%) wassignificantly higher than that in nasopharyngitis tissues (59.4%)(P<0.05).The down-regulation rate of E-cadherin in nasopharyngeal carcinoma tissues was higher than that in nasopharyngitis tissues (P<0.05).(2) Theexpression of FOXC1and E-cadherin were not related to patients＇ageand sex, TNM stages and lymph node metastasis(P>0.05).(3) Thedown-regulation rate of E-cadherin in nasopharyngeal carcinoma tissueswith high expression of FOXC1(52.5%) was higher than the one withlow expression of FOXC1(24.5%), There was a correlation between theexpression of FOXC1and down-regulated expression of E-cadherin innasopharyngeal carcinoma tissues (P<0.05). Conclusions: Expression ofFOXC1and E-cadherin may contribute to the carcinogenesis, and mayplay an important role in the development of nasopharyngeal carcinoma.