| Background and objectiveHepatocellular carcinoma (HCC) is one of the major diseases that threatening the healthof human beings and it has a low radical resection, easy to relapse after the operation. Theintrahepatic metastasis is the most common form of transfer. Hepatocellular carcinoma has apoor prognosis, most patients eventually died of liver metastasis, the overall prognosis is verypoor. In recent years we found myeloid cells play an important role in tumor progression. Ourprevious study found that the Tip-DC (TNF alpha/iNOS producing dendritic cells) hasplayed a very important role in the process of liver metastasis in colorectal cancer and lungcancer, Tip-DCs are actively raise to within the liver metastases; Selectively removal of Tip-DCs can inhibit the growth of liver metastases, and even make some tumor smaller[34]. Soin hepatocellular carcinoma (HCC), whether there is the same or a similar mechanism? Westudy whether Tip-DCs exist in the liver tissue of hepatocellular carcinoma, Aims forproviding new ideas for the clinical prevention and treatment of intrahepatic metastasis ofhepatocellular carcinoma.MethodsWe collected30cases of HCC patients with clinical data and consent integrity ofshandong province cancer hospital during2011~2013,19cases of male,11cases offemale.The tissue samples including hepatocellular carcinoma、the adjacent tumor tissues、peripheral venous blood serum. All cases before the operation did not had any anti-tumor treatment. And we used flow cytometry detect whether Tip-DCs exist in the liver tissue ofhepatocellular carcinoma.ResultsTip-DCs are high expression in liver cancer tissue, in normal liver tissue adjacent tocarcinoma are low expression.ConclusionHCC tissues actively raise Tip-DCs, this may be associated with the invasion andmetastasis of hepatocellular carcinoma. |
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