The Frequency And Clinical Significance Of Myeloid-derived Suppressor Cells In Peripheral Blood Of The Patients With Cervical Carcinoma

Objective:The purpose of this research is to investigate the percentage of myeloid-derived suppressor cells (MDSCs) in peripheral blood of cervical cancer (CC) patients and to assess its clinical relevance. Methods:A total of 80 cervical cancer patients, 30 cervical intraepithelial neoplastic (CIN) patients and 23 healthy donors are included. The levels of CD33+CDllb+HLA-DR-MDSCs in peripheral blood are investigated by flow cytometry. Meanwhile, it also examines MDSC level at 7th day after operation in cervical cancer (CC).Results:We showed that the circulating MDSCs proportion is elevated in CC and CIN patients. Further analyses revealed that the percentage of MDSCs is correlated with advanced stages in CC, but has no relationship with other clinicopathological factors including age, grade, FIGO stage, lymph node invasion and histopathology. And the proportion of MDSC of CIN patients was higher than healthy donors. The proportion of MDSC of cervical cancer patients decreased obviously at the 7th day after operation, and was higher than before the operation; Our results reveal that MDSCs play a significant role in the development and progression of cervical cancerConclusions:1. The proportion of MDSC in peripheral blood of cervical cancer patients is significantly higher than healthy people。 moreover it is closely related to the progression of tumor.2.The proportion of MDSC decreased after resection, which suggests that the immune function recovered in a certain extent.3. It provides a new clue for researching the effect of MDSC in 1.Our results reveal that MDSCs play an important role in cervical cancer and in the future large validation studies may help in the development of new immunotherapeutic strategies to inhibit or eliminate MDSCs function.