The Study About The Risk Factors And TCM Syndrome Of Invasive Pulmonary Fungal Infection

ObjectiveWith the advancement of modern medicine diagnosis and treatment technology, a large number of broad-spectrum antibiotics, cortices-teroids, immune suppressive agents and invasive diagnosis and treatment are widely used in clinical operation, the incidence of invasive pulmonary fungal infection in the ICU has increased year by year. The type of Infected strains is still mainly candida albicans infection, of which the incidence has fallen. However the proportion of non-candida albicans infection has increased year by year, with a high case fatality rate.Despite of more attention by clinical physicians, the western medicine for the diagnosis of invasive pulmonary fungal infection and treatment are very limited, and the curative effect is not very satisfactory yet.This study is to discuss invasive pulmonary fungal infection risk factors and the regularities of distribution of TCM syndrome elements, to explore whether there are different risk factors between candida albicans infection and non-candida albicans, to effectively curb the momentum of candida albicans, also hope to find some new way to treat invasive pulmonary fungal infection of in combination of Chinese traditional and Western medicine treatment, which is of great significance to guide the treatment of invasive pulmonary fungal infection.MethodsThe method of paper subject is retrospective investigation. The paper records the relevant clinical information of patients who are inflected by Invasive pulmonary fungal, divides all cases into candida albicans and non-candid albicans groups and compares the difference between the two groups, distinguishes the difference of risk factors, records the patients’ symptoms (subjective and objective), classifies TCM syndrome elements according to the current generally accepted standard terminology of TCM factors, and analyzes the distribution regularity in the patients.ResultsIn the65cases of invasive pulmonary fungal infection in patients, candida albicans group has44cases, accounted for67.7%of the total number of cases.21cases of candida albicans group, which is accounted for32.3%of the total number of cases. By analyzing the related risk factors, we find that candida albicans and non-candida albicans groups have no statistical difference in age, sex, specimens, APACE II score, mechanical ventilation mode and time, use of antibiotics, invasive species and time diagnosis and treatment measures,(including stomach tube, deep venipuncture, artery catheter, bronchoscopy mirror, CRRT), inflammation, blood products, hypoalbuminemia, number of organ dysfunction, prognosis, parenteral nutrition, hormone, acid inhibitors, and the use of sedative drugs. And Logistic regression analysis hints that he condition of the ICU admission more than5days, the nutrition (prealbuminPA), PaO2and PaC02may be the difference in risk factorsbetween candida albicans infection and non-candida albicans infection.As TCM syndrome elements of65patients who have invasive pulmonary fungal infection are summarized,we find that deficiency and empirical syndrome are more, accounted for81.5%, pure empirical syndrome is accounted for15.4%, while pure deficiency syndrome is3.1%.In deficiency syndromes elements, qi deficiency syndrome frequency is highest, accounting for85.5%, followed by subsequent actions (56.4%), blood deficiency syndrome (27.3%), yin deficiency syndrome (25.5%). In empirical factors of syndromes, phlegm syndrome has the highest frequency, accounted for76.2%, followed by subsequent (50.8%), heat syndrome of blood stasis syndrome (42.9%), wet certificate (22.2%). After comparative analysis, we find that yang deficiency syndrome, blood stasis and water wet in non-candida albicans group is higher than that in candida albicans group. The difference is of statistical significance.ConclusionI. Being in ICU ward more than5days, malnutrition (prealbumin), hypoxemia and carbon dioxide retention may be the difference of risk factors in candida albicans infection and non-candida albicans infection.Ⅱ. Patients with invasive pulmonary fungal infection are more in Deficiency and empirical syndrome. However, The incidence of Yang deficiency syndrome, blood stasis and water wet in patients of candida albicans and non-candida albicans infection is higher. Therefore, clinical treatment of invasive pulmonary fungal infection in promoting blood circulation to eliminate blood stasis and dispel wet, at the same time, the doctor must takeyang-qi of the patient into account, because being sick for a long time will cause consumption of fluid and qi depletion.