Research Progress In Association Between Diabetes/Pre-diabetic Stage And Liver Enzymes

Diabetes mellitus(DM) is a complex metabolic disease characterizedof glucose excess and insulin deficiency, mainly caused by genetic,environmental or immunity abnormal. It is always followed by sugar, fat,protein, water and electrolyte imbalance. Diabetes nowadays is one of themost normal chronic disease all over the world. Patients with diabetesincreasing fast worldwide, especially in developing countries. Tissuehypoxia and ischemia, chronic inflammatory reaction, fatty toxicity causedby diabetes, would lead to multiple organs and systems damage. Expertsalready have a comprehensive research on diabetic complication located inheart, brain, kidney and retina, but studies about liver complication are lack.At present, studies show that diabetes can cause or aggravate multiplekinds of liver damage, such as non-alcoholic fatty liver disease(NAFLD),cirrhosis, tumor, bacterial liver abscess and complications in livertransplantation. At the same time, liver disease can also have adverse effectto diabetes. Liver enzymes are the important sign of liver function. They can be released into blood while liver damaging, increasing theconcentration. Here is to make a review of the current knowledge ofrelationships between liver enzymes and type2diabetes/pre-diabetic stage.