Study On The Dynamic Changes In Serum Levels Of VEGF And BFGF In Patients With Acute Cerebral Infarction

Objectives Observe the dynamic changes of vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF) in serum of patients with acute cerebralinfarction, and to explore the role of both in the pathogenesis of acute cerebral infarctionand the relationship with infarct size and prognosis.Methods Collect150cases of patients with acute cerebral infarction within2days ofonset as cerebral infarction group, the normal control group were age and sex-matchedhealthy people80cases. Taken in patients with acute cerebral infarction2d,7d,14d blood3ml, centrifugal10min with3500r/min, extracted serum and preservation at-80℃refrigerator. Taken control group fasting blood once, processed as above. ELISA was usedto detect the levels of VEGF and bFGF. According to CT or MRI to measure the maximumdiameter of the infarct, applying mRS score to assess prognosis after three months. All thedata obtained were arranged by the EXCEL database and then analyzed by SPSS13.0statistics software. Count data were expressed as a percentage, significant test using χ2test,measurement data were presented as mean±standard deviation(x±s), parameters betweenthe two groups were compared using independent t test, among groups were comparedusing univariate analysis of variance, with P<0.05was considered statistically significant.Results1Hypertensive patients with cerebral infarction, the incidence of diabetes andhypertensive of cerebral infarction group are higher than control group, the differencewas statistically significant,The age, gender, smoking, alcohol consumption,hyperlipidemia was no significant difference in percentage between the two groups.2Compared with the normal control, the levels of VEGF began to increase in the2d,reached a peak at7d and began to decrease in the14d. bFGF levels in the first2d afterinfarction is highest,7d begain to decrease,14d to a minimum, but still higher than thenormal control.3Compared with the level of VEGF and bFGF in purely cerebralinfarction group and cerebral infarction group of risk factors at different time points aftercerebral infarction, the difference was not statistically significant.4Serum levels ofVEGF and bFGF is related with infarction area. The same point in time, the level ofVEGF and bFGF of a large infarction were significantly higher than those in medium andsmall infarction.5Comparison of serum levels of VEGF and bFGF in patients with relatively moderate and large area of infarction, in2d,7d,14d the good prognosis groupwere significantly higher than the poor prognosis group, the difference was statisticallysignificant.Conclusions1The expression of VEGF and bFGF were increased in patients with acutecerebral infarction, and showed the dynamic changes with the progress of the disease.2No significant differences in the expression of VEGF and bFGF in patients with cerebralinfarction risk or not..3With infarction area increases, the levels of VEGF and bFGFtended to increase, suggesting that the size of cerebral infarction may be related to theexpression of VEGF and bFGF.4The levels of VEGF and bFGF in patients with goodprognosis are higher than the poor prognosis patients with the same infarct size.