| Objective We retrospectively reviewed the clinical features and prognosisrelated factors of children with a diagnosis of GBS in Ningxia hui autonomousregion for the time between January2003and December2012. Clinical features ofGBS patients with demyelination and patients with diffuse axonal injury are alsocontrasted and analyzed.Methods We retrospectively analyzed the88patients of GBS from theCDC of Ningxia monitoring children (<15) AFP cases between January2003-December2012. All diagnoses of patients are in line with Chinese Journal ofPsychiatry1993Editorial Board of the development of GBS diagnostic criteria.We described the epidemiological characteristics of pediatric GBS patient’s suchas age, sex, season and residential location, etc. The6-point Motor DisabilityGrading Scale (Hughes scale) is a useful tool in the evaluation of patients’disabilities and enables a unified analysis for GBS clinical research, despite someshortcomings. Regretfully, it has not been widely used by pediatricians in manyregions of China in the past, including our center. According to EMG resultspatients were divided into two groups, axonal damage group and demyelinationinjury group, in which certain clinical features and efficacy were compared. Thecondition of patients were divided into light, medium and heavy; according to thedifferent treatments of plasma exchange, the treatment groups were divided intoimmune globulin treatment group, hormone therapy group; according to clinicalrecovery after treatment of2weeks, they were divided into effective and ineffective group, to compare the efficacy of different treatment groups givendifferent treatment under the same conditions.Results88GBS patients including46males and42females were selected.Age of onset is about5-10years old, with more onset in summer. In term ofprevious infection, patients mainly with upper respiratory tract infectionsaccounted for44.31%. In all cases, we found patients’ muscle strength reduced bythe objective examination, in which patients with strength reducing from upper tolower limb accounted for42.04%. Cases with tendon reflexes disappearing weremore common, accounting for55.68%, with34cases having depressive symptomaccounting for20.45%, more than adults.54.54%patients had cranial nervedamage,29.55%of patients with autonomic nerve damage. Patients withrespiratory muscle involvement were12cases, accounting for13.64%, four casesrequiring tracheostomy and assisted ventilation, accounting for4.55%.8cases hadrespiratory infections which is the most common complications, accounting for20.45%.77cases had lumbar puncture, in which cases with cerebrospinal fluidprotein-cell separation accounted for72.72%. All electrical conduction testresults showed patients with neurological abnormalities. Compared withdemyelinating group, Axonal injury group in terms of the previous infection hadmore diarrhea and less upper respiratory tract infections, with P <0.05significantdifference. There were no dramatic difference between both groups in respect ofgender, age, time, regional distribution, with P>0.05; the efficacy of the twogroups and no significant difference (P>0.05). There was no statistical differencein efficacy（P>0.05）. The immunoglobulin and plasmapheresis groups had nostatistical difference with the same state of illness.(P>0.05)Conclusion According to the study, we find the epidemiologic features andclinical features of88patients of GBS in Ningxia are basically in accordance with the findings abroad. No difference between Men and women in the term ofincident rate. Children tend to get this disease in the age of5-10. Compared withadults, children have more pain symptom. In terms of previous infection, twogroups had statistical differences. |
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