The Study Of Hormone Therapy In Treatment Of Primary Nephrotic Syndrome And The Intrinsic Link Between Chinese Medicine Syndrome

ObjectiveBased on 201 cases of primary nephrotic syndrome (Primary nephrotic syndrome, PNS) with glucocorticoid stage process in the main vein of hospitalization, understand the law of TCM syndromes in the process of change, is effective in the treatment of PNS provide the basis for the combination of traditional Chinese and Western medicine, in order to guide the clinical work.MethodsTo collect 201 cases with PNS of glucocorticoid patients Which include the clinical data of TCM pulse dose reduction of before treatment, the treatment of early stage (1-4 weeks), in the treatment of late enough (5-8 weeks), in the main stage and maintenance treatment stage in the process. Surface observation to formulate a unified, the main symptoms, PNS hormone therapy may occur in the process of signs, tongue, pulse condition in all cases of clinical observation, and then the symptoms, tongue, pulse condition accurately and faithfully to login to the observed cases. Don’t do first set sentenced the TCM syndrome, after the observation, according to the standard of TCM syndrome diagnosis, differentiation of PNS standard to determine the TCM syndrome types,and the corresponding statistics analysis, to investigate the changes of TCM syndrome before and after treatment.ResultsFirst, the deficiency of the hand, comparison of different TCM Syndromes of age, no significant difference (F=1.865, P=0.102);Comparison of different TCM Syndromes of sex.no significant difference (x 2=0.765, P=0.979);A comparison between the different stages and different hormone medication of TCM syndrome, there were significant differences (x2=373.153, P=0.000).There was lung and kidney qi deficiency, spleen and kidney qi deficiency, spleen kidney yang deficiency syndrome beofer gluococrtiocsteorid treatment, with spleen and kidney qi deficiency (75.6%) mainly; Adequate treatment of early 1-4 weeks, there was spleen and kidney qi deficiency, deficiency of both qi and Yin Syndrome, which deficiency of both qi and Yin (63.6%) mainly; In late enough in the treatment of 5-8 weeks, there was a deficiency of liver yin and kidney yin, deficiency of both qi and yin syndrome, wich liver and kidney yin deficiency (57.1%) mainly; Reduction stage, there was lung and kidney qi deficiency, spleen and kidney qi deficiency, spleen and kidney yang deficiency, qi and yin deficiency, both yin and yang deficiency syndrome, which qi and yin deficiency(63.3%)mainly;Main maintenance phase, there was spleen and kidney qi deficiency, spleen and kidney yang deficiency, both yin and yang deficiency syndrome, which spleen and kidney yang deficiency(43.9%)and both yin and yang deficiency (36.5%) mainly.Second, standard empirical comparison of different TCM syndromes, age, no significant difference (F=2.039, P=0.062);Comparison of different TCM Syndromes of sex, no significant difference (x2=1.069, P=0.784);A comparison between the different stages and different hormone medication of TCM syndrome, there were significant differences (x2=94.266, P=0.000).There was dampness syndrome (34.1%), damp-heat syndrome (24.4%), the wet muddy syndrome (29.3%) and blood stasis syndrome (26.8%) beofer gluococrtiocsteorid treatment; Adequate treatment of 1-4 weeks and 5-8 weeks, which damp-heat syndrome mainly, accounted for 61.2% and 50%;Reduction stage, in addition to dampness syndrome, the damp-heat syndrome (43.2%), the wet muddy syndrome (50.0%) and blood stasis syndrome(31.8%) were obviously; The maintenance phase, the highest proportion was dampness syndrome, which accounted for 68.3%, blood stasis syndrome accounted for 26.8%. The blood stasis runs through the whole course of treatment.ConelusionPNS patients showed dynamic changes in TCM syndrome type to use hormone therapy process. The deficiency of the hand, showing the evolution lawde of spleen and kidney qi deficiencyâ†' spleen and kidney qi deficiency or both deficiency of qi and yin mainlyâ†' liver and kidney yin deficiencymainlyâ†' qi and yin deficiency mainlyâ†'yin and yang both deficiency or spleen and kidney yang deficiency. Standard empirical aspects, showing the evolution lawde of dampness syndrome, damp-heat syndrome, wet muddy syndrome and blood stasis syndrom obviouslyâ†'damp-heat syndrome mainlyâ†'amp-heat syndrome, wet muddy syndrome and blood stasis syndrom obviouslyâ†'wet muddy syndrome and blood stasis syndrome mainly. In the whole course of treatment, blood stasis syndrome and wet muddy syndrome were more prominent. Blood stasis wet muddy syndrome throughout the course of the disease from beginning to end.