Study Of Influential Factors Of Peptic Ulcer Patients In The Sourthern Part Of Shandong Province

PurposeThis research aims at analyzing the main factors related to the incident of peptic ulcerand providing references to clinic prevention, diagnosis and treatment of peptic ulcer inthis area through the comprehensive research of patients with peptic ulcer in the southernpart of Shandong Province, which includes their background, dietary habits and cliniccharacteristics.MethodThe hospital-based case – control study method was applied and case collection wasconducted according to a unified enrollment and exclusion criteria. 318 diagnosed cases ofpeptic ulcer hospitalized between January 2012 and June 2013 were selected and set in theexperimental group, and 420 cases of healthy people of admission examination in thecorresponding period were selected as the control group. Questionnaire survey and indexanalysis were conducted on these research objects of background, habits, oral medicationhistory and psychological factors. The database was constructed with Epidata3.1 and alldata was analyzed. Univariate and multivariate analysis of the main factors of peptic ulcerwere conducted with the application of SPSS software.Result1、univariate analysis1.1 In experimental group, there were 232 male which accounted for 72.96% and 86 female which accounted for 27.04%; in control group, there were 221 male whichaccounted for 52.62% and 199 female which accounted for 47.38%, the difference wassignificant(P<0.05). In experimental group, there were 69.50% manual and 30.05% mental,in control group, they were 70.00% and 30.00%, the difference was significant(P<0.05).In experimental group, people with cardiovascular disease history accounted for 79.56%and people with autoimmune disease accounted for 1.89%, and those in control group were54.67% and 0.95%, the difference was significant(P<0.05). In experimental group, therewas 69.50% people with Hp infection and 51.90 % in control group, the difference wassignificant(P<0.05). Age and education in both groups were comparable but there was nosignificant difference(P >0.05).1.2 Experimental group had 64.47% for set-smoking, 31.13% for alcohol, 61.01% forregular life, 55.97% for regular dietary, control group had 53.10% for set-smoking, 18.57%for alcohol, 21.67% for regular life, 72.14% for regular dietary, there was significantdifference between these two groups(P<0.05). Sleeping time of both groups wascomparable but no big difference(P>0.05). See table 3 for detailed information. Fordietary survey, both groups were different in following aspects: fried food, smoked andpickled food, spicy food, strong tea, coffee and milk.1.3 For project score≥3 of the nine factors in SCL-90, in experimental group, theywere anxiety(100.00%), depression(100.00%), interpersonal sensitivity(80.00%),obsessive-compulsive disorder(50.00%), hostility(40.00%); In control group, they wereanxiety(30.00%), and interpersonal sensitivity(30.00%), there was significant differencebetween these two groups(P<0.05). See table 5. HAMA score in the experimental groupwas 2.58 ± 1.17, HAMD score was 12.38 ± 3.68, the control group was 1.06 ±0.25,5.88 ± 0.76, the difference was significant(P <0.05).1.4 In the experimental group, not taking NSAIDs was 66.67%, 13.20% forShort-term medication and long-term medication was 20.13%; the control group was90.47%, 5.48%, 4.05%, the difference was significant(P <0.05).2 multivariate analysisAfter Logistic regression analysis, factors affecting the incidence of PU weredetermined by history of cerebrovascular disease, HP infection, smoking, irregular life,eating disorders, spicy foods, coffee, tea, milk, anxiety, depression, NSAIDs medicationhistory, and milk was the protective factor.Conclusion1. The relevant factors affecting the incidence of PU in the southern part of ShandongProvince were gender, occupation, history of cardiovascular disease, NSAIDs likemedication, HP infection, smoking, drinking, irregular life, irregular dietary, fried foods,smoked pickled foods, spicy foods, coffee, tea, milk, mental factor of depression as well asNSAIDs medication history, of which milk was the protective factor.2. People should maintain good living habits, like keeping a routine life, staying awayfrom drinking and smoking, having a sensible dietary, avoiding such hard food as spicypickled foods and fried pancake, averting irrational use of NSAIDs and other drugs. Allthese are good for the prevention and treatment of PU in the southern part of Shandongprovince.