Observation Of Alisma Tiaozhi Granule On The Clinical Effect Of The Treatment Of Nonalcoholic Fatty Liver Disease Of The Spleen With Overabundance Of Dampness And Phlegm-Damp Retention

Objective:This study of alisma tiaozhi granule side improve the phlegm and blood stasis type of pixu (spleen deficient) in patients with nonalcoholic fatty liver disease clinical efficacy, safety, observation and evaluation, provide relevant basis for traditional Chinese medicine treatment of nonalcoholic fatty liver disease.Methods:Would be consistent with clinical diagnosis standard and this research into 60 cases of patients, according to the random scale, divided into the treatment group 30 cases and control group 30 cases. Treatment group given alisma tiaozhi granule oral treatment, control group given is good after oral treatment, for 12 weeks of treatment and observation on two groups of clinical curative effect, Chinese medicine syndrome curative effect, symptom improvement and adverse reaction and safety indicators were compared.Results:n terms of lipid levels adjustment, alisma tiaozhi granule party with good complex group can effectively improve the lipid levels in patients with nonalcoholic fatty liver disease (TC, TG, LDL-C, HDL-C (P<0.05); Alisma tiaozhi granule group of adjusting TG, LDL-C is better than good easily after group (P<0.05); Alisma tiaozhi granule party group adjust the effect of TC, HDL-C with good after treatment group (P> 0.05);In liver function abnormal rate, alisma tiaozhi granule fang yi good complex group can effectively reduce the patients with nonalcoholic fatty liver disease of transaminase (AST, ALT, etc.) (P<0.05); Alisma tiaozhi granule party group to improve the ALT abnormal rate is better than that of is good after group (P<0.05), can be thought of as two drug treatment.Syndromes curative effect, there are 7 cases of clinical recovery, the treatment group takes effect in 12 cases,9 cases effective,2 cases of void and the control group 6 cases of clinical recovery,13 cases, were markedly improved in 10 cases,1 case was ineffective, visible use alisma tiaozhi granule party of traditional Chinese medicine (TCM) and western medicine is good after the syndrome curative effect has no significant difference (P>0.05). In terms of symptom improvement, alisma tiaozhi granule party group of the improvement of clinical symptoms such as fatigue, food in god group and western medicine is good after curative effect without obvious difference (P>0.05); In improving abdominal distension, limbs were heavy, breast symptoms such as swelling in aspects of alisma tiaozhi granule party group is superior to western medicine is good after group (P<0.05). In terms of safety, clinical use of alisma tiaozhi granule parties use patients after three, liver and kidney function, electrocardiogram (ecg) are not found obvious abnormal changes in the security check.12 weeks of clinical observation period were found abnormal performance.Conclusion:Alisma tiaozhi granule can reduce phlegm stasis in patients with nonalcoholic fatty liver disease (pixu (spleen deficient) god fatigue, weakness, abdominal distension, arms and legs were heavy, chest, a bloated with wait for a symptom, the particles of clinical curative effect is observed, alisma tiaozhi granule treatment of nonalcoholic fatty liver disease clinical observation period, no side effects, and other adverse reactions report found.