Clinical Observation And Study Of Mechanism Of Silver Particles Zhi Lotion Fumigation In The Treatment Of Acute Attack Of Hemorrhoids

Objective: To observe the silver particles Zhi lotion, Yinzhi anorectal fumigation lotion fumigation hemorrhoids patients before and after treatment in the treatment of acute exacerbations(by self-made hemorrhoids acute exacerbation of main symptom score), curative effect by statistical methods comparison of the two, and through animal experiments to examine the effectiveness for Yinzhi anorectal lotion products improved the formulation of silver particles in the treatment of hemorrhoids lotion Zhi promotion in clinic and Provide a theoretical basis for perianal common diseases. Methods:1 clinical observation: 70 cases of Patients with acute onset of hemorrhoids, according to statistical methods 70 Patients were randomly divided into treatment group and control group of 35 cases. The treatment group was given Yinzhi granule lotion, the control group was given Yinzhi anorectal fumigation lotion, continuous smoked wash for 7 days, respectively, after treatment 24 h, 48 h, 168 h were observed in patients with anal pain, edema, blood in the stool, mucous membrane changes, and through these main symptoms according to the self score table score, then the statistical analysis of the data.2 Study on mechanisms: mainly through animal experiments: effects of Paw edema induced by carrageenin in rats, anti-inflammatory effects of xylene induced auricle swelling in mice on silver Particles Zhi lotion; effect of heat induced Pain in mice, the analgesic effect induced by acetic acid writhing experiment on silver Particles of Zhi lotion the mouse tail bleeding time; hemostatic effect experimental study of silver Particles of Zhi lotion.Results:1 Yin Zhi particles smoked lotion, Yinzhi anorectal lotion fumigation in the treatment of acute hemorrhoids after 7 days, the total efficiency was 91.43% and 88.57%, P > 0.05(0.716) show no significant difference. Treatment group(Yinzhi particles lotion) patients after treatment for 24 h, 48 h and 168 h pain degree, blood in the stool, edema, mucous membrane change scores were significantly lower, but after 168 h to pain and bloody stool score decreased more significant, P < 0.05(P respectively 0.002 0.002). The degree of edema and mucosal changes after treatment with 48 h were not significantly decreased, and the score of P > 0.05(P = 0.083, 0.061) showed no significant difference. Inferred: treatment group of drugs(Yinzhi particles lotion) within 48 hours of improvement in patients with edema and mucosal significantly change the effect. The control group(Yinzhi anorectal fumigation lotion) patients after treatment for 24 h, 48 h and 168 h pain degree, blood in the stool, edema, mucous membrane change scores were significantly lower, but after 168 h to pain and bloody stool score decreased more significant, P < 0.05(P respectively 0.002 0.002). The degree of edema and mucosal changes after 48 h were not significantly decreased, and the score of P > 0.05 showed no significant difference. Inferred: control group of drugs(Yinzhi anorectal fumigation lotion) within 48 hours of improvement in patients with edema and mucosal significantly change the effect.2 carrageenan rat Paw swelling experiment: Yinzhi granules fumigation high, middle dose in different time period compared with the model group, P < 0.05, showed that the silver particles fumigation, Zhi high dose could significantly inhibit the paw edema caused by carrageenan in rats. Xylene induced ear swelling experiment: model group P < 0.05, aspirin gavage group P=0.013 < 0.05; silver Zhi granules fumigation high dose gavage group P=0.023 < 0.05; silver Particles Zhi lotion low dose gavage grou P P=0.037 < 0.05 indicates significant difference, indicating that aspirin, Yin Zhi Particle lotion(gavage) high, low dose could inhibit xylene induced ear swelling in mice. The mice Pain threshold: experimental group, silver Zhi Jin Xuan lotion lotion Particles respectively, compared with the previous administration of P < 0.01, the experimental results and statistical analysis of the results can be concluded: Yinzhi granules fumigation group and Jinxuan lotion group can improve the thermal pain threshold of mice. Mice caused by acetic acid writhing experiment: aspirin group compared with model group, P < 0.01, Yin Zhi lotion in high dose group, low dose of Yinzhi lotion group compared with model group, P < 0.05, suggesting that aspirin, silver Zhi lotion high dose, low dose of Yinzhi lotion can reduce acetic acid rats induced by writhing, silver Particles that Zhi lotion has obvious analgesic effect, bleeding time after experimental mouse tail: Yunnan Baiyao group, silver Particles(high), Zhi Zhi(in) the silver Particles and the bleeding time of model group comparison between the two two groups had significant difference(P < 0.05), show that Yunnan Baiyao Silver Particles(high), Zhi Zhi, silver Particles(in) doses could shorten the bleeding time of mice tail. Conclusion: Silver Particles Zhi lotion all Parties to play Qingrejiedu, Qi and blood stasis, alleviating pain, can significantly improve the main symptoms of hemorrhoids patients with acute exacerbation of silver Particles, Zhi lotion has anti-inflammatory, analgesic and hemostatic effect, the dosage form is stable, easy to carry, the clinical curative effect and no Yinzhi anorectal fumigation Lotion the obvious difference, that improved the formulation of success.