The Correlation Between Helicobacter Pylori Infection And Coronary Heart Disease

Objective: This study is to investigate the relationship of Helicobacter pylori(H.pylori) infection with coronary heart disease(CHD), especially with the number of coronary lesion vessels and many risk factors for CHD, observe the effect of H.pylori infection on lipid metabolism, inflammatory mediators and the balance of body’s blood coagulation and fibrinolysis system, and discuss the pathogenesis of CHD induced by H.pylori infection.Methods: The cases in this study were selected from the patients who were hospitalized and performed coronary angiography in heart internal medicine of our hospital, according to the coronary angiography results, the patients were divided into two groups: positive coronary angiography group with 154 cases, which were further divided into single lesion group with 64 cases, double lesion group with 52 cases and three branch lesion group with 38 cases according to coronary lesion vessels counts, and there were 100 cases in normal coronary angiography group, and excluded diagnosis of CHD. H.pylori infection rate of the two groups was detected by 13C- breath test or 14C- breath test, and the patients’ age, gender, body mass index, smoking history, hypertension history and diabetes history was synchronously observed and analysed. For the patients’ blood of the two groups, total cholesterol(TC), triglyceride(TG), lipoprotein A [LP(a)], high-density lipoprotein(HDL), low density lipoprotein(LDL), hypersensitive c-reactive protein(hs- CRP) and the change of fibrinogen(FIB) was detected, and the correlation between these indicators and H.pylori infection was analyzed.Results:1. H.pylori infection rate in the positive coronary angiography group is 66.23%(102/154), significantly higher than that in normal coronary angiography group with 37%(37/100), the difference between them is statistically significant(P< 0.05).2. H.pylori infection rate in single lesion group, double lesion group and three lesion group is respectively 56.25%(36/64), 69.23%(36/52) and 78.95%(30/38), the difference is not statistically significant(P>0.05). H.pylori infection rate of normal coronary angiography group is 37%(37/100), comparing with that of the single, double and three lesion groups shows statistically significant difference between them(P<0.05).3. H.pylori infection have nothing to do with the CHD risk factors, such as, age, sex, body mass index, smoking history, history of hypertension and history of diabetes(P>0.05).4. H.pylori infection is connected with total cholesterol, triglyceride, low density lipoprotein cholesterol, lipoprotein A, allergic C- reactive protein and fibrinogen levels(P< 0.05).Conclusions:1.H.pylori infection have significant correlation with coronary heart disease, H.pylori infection may be one of the etiological factors.2. Comparing H.pylori infection rate in the single, double and three lesion groups shows that the more involved coronary lesion vessel was, the higher the H.pylori infection rate is.3.H.pylori infection have correlation with total cholesterol, triglyceride, low density lipoprotein cholesterol, lipoprotein A, fibrinogen and hypersen- sitive C- reactive protein.