Relationships Between Preoperative Neutrophil Lymphocyte Ratio, Platelet Lymphocyte Ratio, Serum Lipid Level And TNM Staging Of Tongue Carcinoma

Background & Purpose:Currently, preoperative neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) have been proven closely related to various cancer TNM staging and prognosis. However, correlations between NLR, PLR, blood lipid level and tongue carcinoma TNM staging were less studied. The aim of this study was to investigate correlations between preoperative NLR, PLR, serum lipid level and TNM staging of tongue carcinoma.Methods:Fifty-four cases of tongue carcinoma were retrospectively analyzed between 2009 and 2011 in Department of Oral & Maxillofacial Surgery of Qilu Hospital Shandong University. Basic clinical characteristics of patients (sex, age), postoperative pathologic lesions of TNM staging and preoperative routine blood tests results within 2-7 days (absolute neutrophil white blood cells, lymphocyte absolute value absolute value absolute value and platelet and blood lipid levels) were collected. Neutrophil lymphocyte ratio (NLR) was defined as the ratio of absolute value of absolute neutrophils and lymphocytes, and platelet lymphocyte ratio (PLR) was the ratio of absolute value of platelet and lymphocyte absolute value. Spearman rank correlation test was applied to estimate the correlation between NLR, PLR and cancer TNM staging, while independent sample t test was applied to estimate the correlation between serum lipid level and cancer TNM staging. The obtained data were analyzed by SPSS 17.0 software package, and P<0.05 demonstrated the significance.Results: Among 54 cases of tongue carcinoma, squamous cell carcinoma accounted 38 cases, mucoepidermoid carcinoma 3 cases, adenoidcystic carcinoma 2 cases, acinic cell carcinoma 1 case and myoepithelial carcinoma 1 case.36 cases of Male patients and 18 cases of female patients.16 cases of TNM stages T1,20 cases of T2,4 cases of T3 and 9 cases of T4.26 cases had no lymph node metastases (NO),18 cases with Nland 10 cases with N2.2 cases of Ml, while the others were all for MO.NLR and PLR were calculated by collected data, and Spearman rank correlation test were applied to test NLR, PLR and cancer TNM staging, tumor size, lymph node metastasis. None had a significant correlation (PMLR&T=0.552>0.05;PNLR&N=0.297> 0.05;PNLR&TNM=0.42>0.05; PPLR&T=0.149>0.05;PPLR&N=0.062>0.05;PPLR&TNM=0.127 >0.05). And also, there was no significant difference between different histological classification of patients and TC, HDL, LDL, TG levels (P>0.05).Conclusions:1 There’s no significant correlation between neutrophil lymphocyte ratio (NLR) and TNM Staging of Tongue Carcinoma;2 There’s no significant correlation between platelet lymphocyte ratio (PLR) and TNM Staging of Tongue Carcinoma;3 There’s no significant correlation between serum lipid level and TNM Staging of Tongue Carcinoma.