| Objective Acute pancreatitis(AP) is a severe digestive system, with acute onset, rapid progr ession, severe illness, a variety of complications, high mortality characteristics, is more common in Department of internal medicine and Department of general surgery clini cal work. In the most common cause of China for biliary calculi, ethan ol andovereati ng[1]. The pathogenesis is complex, excessive activation with try ps in auto digestion a nd leukocyte,recognized as the pancreatic duct system due to many causes a transient or persistent obstruction, pancreatic juice is released from pancreatic acini leads itself t o be digested, blood will be after necrosis tissue into theperipheral the formation of sm all circulation, thrombosis ofsmall circulation dysfunction, and tissue from ischemia and hypoxia gradually appear necrosis. Because the AP onset of urgent, espec ially the sev erity of SAP and changes very fast, high mortality, so as soon as possible to make a diagnosis and timely application of targeted treatment to reduce the mortality of grea t significance. Procalcitonin(PCT) as a kind of inflammatory mediators can beenhance d because of infection and inflammatory response induced by [2]. PCT the severe infe ction of advancedlaboratory project, forecast the infection and assessing their degree o f influence of very high [3]. Procalcitonin in the physiological condition of human bo dy under normalconcentration is very low, when the bacterial infection levels will rise, but the virus infection, rheumatic diseases andmalignant tumors and focal infection, PC T concentrationfluctuations in the normal reference value range or only slightly higher, so the test drop procalcitonin to determine whether there is infection specificity. AP in the initial onset of PCT was significantly higher in the severity of illness,and and A P closely, so the PCT can be used for diagnosis of AP and prediction of its prognosis. The level of PCT in AP early as early judgement of severe acute pancreatitis,and ca n timely and effective treatment can reduce the mortality rate, improve the quality of life of patients.Through the research that, PCT in the diagnosis of diseaseinfection an d infection degree angle can prompt the body,on the other hand, as the inflammation medium itself has also affected the development of the disease. The severity of diseas e and therefore monitoring procalcitonin not onlyto determine the acute pancreatitis, als o can be used to observe the effect of drug treatment. Traditional Chinese medicin e Xuebijing by Tianjin Hong Ri pharmaceutical Limited by Share Ltd producti on, this p roduct has Xiaoyu Sanjie, reduce endoto xin, correct cycle dysfu nction effect.The tre atment of pancreatitis of antibiotics based on the use of this product can im prove the cure rate, other organs and system function damage induced by inflammatory medi ators to prevent infection produces, but also weakened the effect of induced disease of the body. On the basis of conventional therapy plus Xuebijing, in the pathogenesis of acute pancreatitis and early, to alleviate the systemic inflammatory respon se syn drome patients by reducing the number of inflammatory medium in circulat ion(SIRS) d egree, fast rehabilitation in acute pancreatitis. This paper aims at the appli cation of X uebijing in treatment of acute pancreatitis, observe the changes of serum PCT levels i n patients with, understand the effects of Xuebijing Injection on the prognosis of pati ents with acutepancreatitis.Method In acute pancreatitis in our hospital in 2013 February-2014 year in Jan uary the Department of internal medicinehospital(AP) patients were random ly selected 60 cases,male patients accounted for 31 cases, 29 cases of fema le patients, aged 40.5-60.8 years old. All patients met thediagnostic criteri a of acute pancreatitis "classification anddefinition of international expert co nsensus---- 2012 edition" of atlanta. All the selected object because the ca use of common bile duct stones and other reasons of the duodenal ampull a obstruction at various reason or stenosis of the sphincter of Oddi; seriou s disease at the same time other organ or other infections patients; special populations such as children, pregnant or: in lactating women; pre hospital has used traditional Chinese Medicine patients were excluded. Random single blind, the patients were divided into Xuebijing treatment group of 30 cases,including 16 cases of male, female 14 cases, age 40.8-60.2 years old, average 50.5 ± 9.7 years old; conventional treatment group of 30 cases, 1/2 for male patients, 12 female patients, aged 40.5-60.2 years, mean 50.35 ± 9.85 years old. Two groups of patients were tested in blood lipid and glucose, between the two groups in age, sex, body mass index, the numbe r of cases of alcoholism, Gao Zhi inthe cases and the incentive distributio n had no significant difference(P>0.05), with comparable. Conventional tr eatment group were given basic support therapy: that decided to stay in b ed, monitoring of vital signs, fasting, continuous gastrointestinal decompre ssion, to prevent water imbalance and acid-base disorders; somatostatin, red uce gastric acid secretion decreased enzyme activity. Xuebijing in the treat ment group within 24 h after admission on the basis of conventional therap y plus normal saline 100ml+ Xuebijing injection 50 ml intravenous drip, t wo times a day, intravenous drip for 1 weeks. Xuebijing group and routine treatment group were within 24 hours of admission, admission 3D, 7d i n the morning blood a. In the early morning fasting collected venous blood 3ml, plasma PCTlevel. Procalcitonin was determined by immunofluorescen ce assay for detecting; application of Guangzhou Buddha medical biologic al Limited company to provide flight test procalcitonin quantitative kit in the automatic biochemical analyzer for testing and to provide the data.Result The blood serum of patients with acute pancreatitis will nettreatment o f procalcitonin decreased significantly, there was statistically significant diff erence compared with the control group(P<0.05); no statistical significanc e of Xuebijing group and routine treatment group. The two groups before t reatment of procalcitonin(P>0.05)difference. Xuebijing group patients after p rocalcitonin levels decreased significantly, compared with that before treatm ent was statistically significant(P<0.01). Compared with the conventional tr eatment group after treatment the difference has statistics significance(P<0.05). Xuebijing group and routine treatment group after treatment, clinical effic iency, abdominal pain, abdominal distension, reduce time to time of blood an d urine amylasenormally required for a short time, the difference was stati stically significant(P<0.05).Conclusion 1 Xuebijing injection treatment process can effectively relieve the pai n degree of patients.2 Xuebijing injection can effectively reduce the duration of patients w ith abdominal pain and distension and blood and urine amylase recovery tim e.3 By antagonizing endotoxin antagonist Xuebijing,inflammatory cytokine role effectively reduce the serumprocalcitonin level. The study enrolled pati ents amount slants little, curative effect monitoring time is not long,clinical observation confirmed yet to large-scale long time. |
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