Esophageal Dynamic And Laryngopharyngeal Reflux Play A Role In Pathogenesis Of OSAHS

Objective:Through monitoring esophageal dynamic change, detection of laryngopharyngeal reflux and gastroesophageal reflux events, to discuss the relationship of OSAHS with laryngopharyngeal reflux. Methods:Thirty patients with OSAHS were diagnosed by polysomnography in the Xinjiang autonomous region people’s hospital between February 2013 and June 2014. This study applied high-resolution esophageal manometry and ambulatory 24-hour multichannel intraluminal impedance-pH monitoring to obtain the upper esophageal sphincter pressure and lower esophageal sphincter pressure, characteristics of sectional esophageal motility; laryngopharyngeal reflux and gastroesophageal reflux events, as well as the reflux properties of substance. Ten healthy persons were recruited as normal controls. Results:UES relaxation duration, duration of UES relaxtion time, UES relaxtion recovery time and mean length of LES were all shorter than those of the control group(t were-2.061、-2.044、-2.525、-2.076 and 2.522, P<0.05). Median scores of Demeester were11.3[5.1; 37.8]and3.8[2.8; 11.1] in OSAHS group and the controls, median frequency of total reflux episodes were 41.5[23.8; 65.3] and 24.5[16.3; 27.8]. The frequency of total reflux episodes, time of acid clearance, Demeester scores were increased or higher in OSAHS group than those in the controls(z were -2.438、-2.361 and -2.140,P<0.05).Conclusions:There are upper esophageal sphincter and lower esophageal sphincter dismotility in OSAHS patients. Esophageal dynamic disfunction should be considered in the study of the pathogenesis of OSAHS.