Comparision Of Clinicopathologic Features And Expression Of HMLH1、hMSH2 In Uygur And Han Patients With Colorectal Carcinoma

Objective:To investigate the clinicopathological features and expression of h MLH1 and h MSH2 in Uygur patients with colorectal carcinoma and its difference with that in Han patients.Methods:The clinical data of Uygur patients with colorectal cancinoma were analyzed retrospectively.The expression of h MLH1 and h MSH2 proteins was detected in the 207 colorectal carcinoma samples by immunohistochemical staining.Including 98 cases of Uygur and 109 cases of Han nationality.Results:There were significant differences in onset age, tumor size,pathological differentiation and tumor stage between Uygur group and Han group( P<0.05). In Uygur the loss rate of h MLH1 expression was 9.2%(9/98) in colorectal cancer tissue. And the loss rate of h MSH2 expression was 3.3 %(3/98).The loss rate of h MLH1 expression in patients with tumor size>5 cm and tumor size≤5cm was17.1%and 3.5%respectively, and the difference was statistically significant(P<0.05).The loss rate of h MLH1 expression in patients with lymph node metastases was 15.1%, significantly higher than that(2.2%)in tumors without lymphatic metastasis(P<0.05). The loss rate of h MSH2 in colorectal cancer tissue of Uygur patients(3.1%) was significantly lower than that(10.1%)in the Han patients(P<0.05),The loss rate of h MSH2 expression was not correlated with tumor size, location,tumor stage, and tumor grade.Conclusion: There are racial differences in clinicopathologic features and expression of h MSH2 between Uygur and Han patients with colorectal carcinoma in Xinjiang.