| Objective: To investigate the therapeutic effect on patients and the effects on serum LP-PLA2, cholesterol, carotid artery thickness(IMT), high-sensitivity C-reactive protein(hs-CRP) by different doses of Atorvastatin calcium, thus further explore the therapeutic effect and therapeutic mechanism of Atorvastatin to atherosclerotic cerebral infarction.Methods: This topic adopts proactive case in random, controlled study. 1.Consecutive selection in our clinic examination of carotid atherosclerosis from August 2013 to December 2014, but 30 normal cases in blood, biochemical, blood lipids, ECG, CT and other tests as the control group without atorvastatin statin therapy. Testing the level of LP-PLA2, hs-CRP in plasma by ELISA;2. Select 60 case in which patients who are hospitalized in neurology in the same period died from acute cerebral infarction atherosclerosis sclerosis that met the diagnostic criteria. According to the statistical method of classification in random into atorvastatin 20 mg treatment group(A) and A atorvastatin 40mgtreatment group(group B), 60 cases are in line with the conditions of this project design and completed, 30 cases each group. The following indicators are tested prior treatment and 12 weeks after treatment:(1) Using the method of Enzyme Linked Immuno Sorbent Assay to test the level of LP-PLA2 and hs-CRP in patients’ serum;(2) Testing the score in United States National Institutes of Health stroke Scale(NIHSS) and the 1987 revision of the modified version of the Battle of Daily Living index(modified barther index, MBI);(3) Testing serum lipids, IMT, liver function. 3.SPSS18.0 software was adopted to process and analyze the data, the setting,P <0.05, was statistically significant.Results:(1)Before treatment, the LP-PLA2 and hs-CRP levels were significantly higher, which has a statistical significance(P <0.05); Before treatment, comparing the average age, gender, IMT, TC, TG, LDL-C, HDL-C, LP-PLA2, hs-CRP, liver, NIHSS score and MBl score of group A and B, it has no statistically significant difference(p> 0.05);(2) After treatment, the LP-PLA2 and hs-CRP levels were decreased, but the degree of decline in group B was significantly greater than that of group A, and the difference has a statistical significance(P <0.05);(3) After 12 weeks of treatment in group A and group B, NIHSS score decreased but MBI score increased, the difference was statistically significant(P <0.05);(4) The lowering effect of atorvastatin: TC, TG, LDL-C of the treatment groups decreased, but HDL-C increased. TC, TG and LDL-C in group B decreased more than that in group A, but HDL-C increased more than that in group A, the differences were statistically significant(p <0.05).(5) The impact of atorvastatin calcium on IMT: IMT in group A and B were reduced, and it was lower in group B, the differences were statistically significant(p <0.05);(6) There is no significant changes in liver function in each group, and it did not generate side effects, such as rhabdomyolysis.Conclusions: Atorvastatin significantly decreased LP-PLA2 and hs-CRP levels in patients with ACI, improving the neurological function, reducing inflammation of ACI patients. And high-dose atorvastatin has a more obvious effect on anti-inflammatory;... |
PDF Full Text Request