Association Of PS Gene Polymorphism And Soluble P-selectin Levelsin Atrial Fibrillation Thromboembolism Population In Xinjiang

Objective:To investigate the association between the polymorphism of P choose element (p. selectin, PS) and soluble P-selectin levels in atrial fibrillation (AF) thromboembolism in Han and Uigur population of Xinjiang.Methods:Using ELISA method determination of plasma level of sPs. The frequency distributions of SNP sP-selectin gene promoter (-2123C/G) and SNP in exon region (Thr715Pro) were investigated by polymerasechain reaction (PCR)-restriction fragment length polymorphism and direct DNA sequence analysis among302 Xinjiang Uigur and 340 age- and sex-matched Han people.Results:Cases sPs exist significant difference serum level and the control group. The frequencies of the -2123C/G allele among the Uigur population had no significant differences from those of the Han population. Thr715Pro did not show anypolymorphism in the two populations.Conclusions:The sP-selectin gene polymorphisms are associatedwith serum sP-selectin levels or thromboembolic events, suggesting that the patients with nonvalvularAF and thromboembolic events may have genetic susceptibility.