Association Of PS Gene Polymorphism With Soluble P-selectin Levels And Atrial Fibrillation Thromboembolism In Kazaks Of Xinjiang

Objective:To investigate the association of the 2123C/G and Thr715Pro polymorphisms of P selectin (PS) with plasma levels of soluble P-selectin in Kazak patients with atrial fibrillation (AF) coupled with thrombosis in Xinjiang.Methods:248 age- and sex-matched Kazak subjects (127 cases subjects and 121 AF patients) were enrolled. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct DNA sequence analysis were used to investigate 2123C/G and Thr715Pro polymorphisms. ELISA method was used to determine plasma levels of SPs.Results:Plasma sPs levels showed significant difference between cases and control groups (p<0.001). The frequency distribution of the 2123C/G and the allele showed no significant differences between cases and control groups(P=0.028 P=0.023). Thr715Pro did not show any polymorphism in Kazak populations.Plasma sPS levels were significantly associated with the 2123C/G polymorphism, and signifiacntly higher in the patients with GG genotype than in those with GC or CC genotype (p<0.05).Conclusion:For Kazak population, polymorphism of 2123C/G locus may increase the risk of thromboembolic events,PS gene polymorphisms are associated with plasma levels of sP-selectin, suggesting that the patients with nonvalvular AF and thromboembolic events may have genetic susceptibility.