Expression Of EMP2 Protein In Breast Cancer Tissue And Its Significance

Introduction & Objectives:Thus, there is an urgent need to discover new moleculartargets.In this study, we investigate the epithelial membrane protein 2(epithelial membrane protein 2,EMP2) expression in human breastcancer. its clinical significance,and explore the relevance of ER and PR,Ki-67 and HER-2 expression in breast cancer.Method: In The Second Affiliated Hospital of University of South China, the author selects the operative specimens of breast tumor, confirmed by pathological diagnosis, as the control group. We collected 30 specimens of breast cancer tissue, and breast tissue with the normal physiological structure and no cancer cell in tissue under the light microscope apart from the edge of breast cancer tissue more than 5cm. Using of immunohistochemistry and western blot, we test the expression of EMP 2 in normal breast group and breast cancer group. Using immunohistochemical techniques for detecting ER, PR, HER-2, and Ki-67 expression in breast cancer.Results: The expression rate of EMP 2 in normal breast group and breast cancer group is 16.7% and 76.7%, respectively. There was significant differences between breast cancer group and normal breast group(respectivelyχ2=21.3348,p=0.0000). The expression of EMP 2 was obviouslyincreased in the breast cancer tissue compared with that in normal tissue. In addition, the expression of EMP 2 was dependent on the histopathological classification, the degree of differentiation and lymph node metastasis in cancer tissue. However, there was no statistical correlation between the level of EMP 2 and the age of patients or tumor size. Expression of ER and PR in breastcancer tissues and EMP2 inco rrelated expression expression in breast cancer.Conclusions: 1, EMP2, is closely related to the incidence of breast cancer. 2, EMP2 overexpression in breast cancer could be harbingers of a poo rprognosis. 3, ER, PR and EMP2 predict the prognosis of patients with breast cancer better. 4, EMP2 in the treatment of breast cancer has the potential to become a new target.