| Purpose: From diabetic rats sciatic nerve growth factor and conduction velocity change and the correlation to explore the intervention mechanism of Yiqihuoxuetongluo Decoction on diabetic peripheral neuropathy.Method: STZ-induced diabetic rats were randomly divided into model group, TCM group, Methycobal group and normal control group. Observe the influence of Yiqihuoxuetongluo Decoction on DPN rats body weight, blood glucose, sciatic nerve growth factor, sciatic nerve conduction velocity.Result: After 8 weeks of treatment, sciatic nerve NGF levels were significantly increased and sciatic MNCV significantly accelerated in diabetic rats, there was a significant difference in medicine with the model group and Methycobal groups.Conclusion: Yiqihuoxuetongluo Decoction can improve the NGF activity and sciatic nerve conduction velocity, to play the role of prevention and treatment of diabetic peripheral neuropathy. |
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