Clinical Research On Treatment Of Lifelong Premature Ejaculation With Syndrome Of Liver Depression And Kidney Insufficiency By Qiaoshaofang

It is well-known that premature ejaculation is a common sexual dysfunetion, but the prevalence of premature ejaculation is still unclear, according to researches we tend to believe that the prevalence rate is approximately 20-30%. Nowdays, several biological factors have been proposed to explain PE, it is noteworthy that none of these etiologies has been confirmed in large scale studies.Traditional Chinese Medicine (TCM) is widely used in treatment of PE in China. According to our research, we found that lifelong premature ejaculation with syndrome of liver depression and kidney insufficiency is the most common. And we used Qiaoshaofang in treatment of PE achieved good results.Objective:In order to study the clinical safety and efficiency of Qiaoshaofang in lifelong premature ejaculation with syndrome of liver depression and kidney insufficiency.Method:A total of 60 outpatients diagnosed with lifelong premature ejaculation who visited andrology department of xiyuan hospital, age range from 23 to 40 years with mean age of (31.47 ± 6.25) years, were enrolled from February 2014 to December 2014,and divided into two groups randomly. In group A,30 Patients took Qiaoshaofang 16g/d for 4 weeks; In group B,30 Patients took dapoxetine 30mg 3 hours before sexual intercourse for 4 weeks. Sex at least once a week. Record the variation in scores of PEDT, intra-vaginal ejaculatory latency time(IELT), sexual life satisfaction and TCM syndrome before and 1,2,3,4 weeks after treatment, observe the clinical efficacy of two groups, adverse events were also recorded. All the data were statistically analyzed.Result:1.30 Patients in group A,the oldest 39 years old, minimum 23 years old, and mean age (29.07±4.38) years.30 Patients in group B, the oldest 40 years old, minimum 23 years old, and mean age (33.35±7.18) years. In group A, 17 patients with mild, moderate in 10 cases,3 cases of severe, In group B,15 patients with mild, moderate in 10 cases,5 cases of severe. In group A, the longest duration of 96 months, the shortest in 13 months, and average(40.97±26.04) months. In group B, the longest duration of 99 months, the shortest in 12 months, and average (42.53±30.98) months. All the baseline characteristics were well balanced between two groups (P>0.05), there is no significant difference in age, clinical course, IELT, PEDT score, TCM symptoms of measurements.2. At the end, group A which have 29 patients, the average ejaculatory latency time of group A was extended from (79.66±37.46) s to (184.13±76.18) s; the average PEDT score was decreased from (15.83±2.30) to (11.76±1.68); the sexual life satisfaction of group A was extended from (4.76±1.12) to (9.28±1.88); the average TCM syndrome score was decreased from (14.86±3.02) to (9.62±2.87). The difference was significant (P<0.001).On the other hand, group B which have 30 patients, the average ejaculatory latency time of group B was extended from (71.50±42.83)s to (272.00±125.79)s, and the difference was significant (P<0.001), the average PEDT score Was decreased from(15.83±2.05) to (10.73±2.96), and the difference was significant (P<0.001), the sexual life satisfaction of group A was extended from(4.17±1.47)to (9.69±1.79);the average TCM syndrome score was decreased from(14.13±3.57)to (10.69±3.02) and the difference was significant (P<0.001)3. In increasing patient’s ejaculatory latency time, group B surpass group A, there are significant differences(P<0.05). In decreasing patient’s PEDT score, there is no significant differences (P>0.05). In increasing sexual life satisfaction, there is no significant differences (P>0.05). In decreasing patient’s TCM syndrome score, group A surpass group B,there are significant differences(P<0.05).4. During the therapy,1 patient in group A had slightly stomach discomfort,3 patients in group B had slightly dizziness and 2 patients had slightly nausea. All the 6 patients can still be tolerated, it did not withdraw from the clinical research, and back to normal after disabled. Group A and the group B were not apparent serious adverse events, indicating that Qiaoshaofang is safe and effective.5. After 4 weeks,1 example was lost in group A, while group B was zero.Conclusions:Qiaoshaofang significantly extend the ejaculatory latency time and decrease PEDT score of Patients with low adverse effect rate. Qiaoshaofang is a safe and effective drug for lifelong premature ejaculation.