The Differences Of Coagulation And Fibrinolytic Markers In The Third Trimester Of Pregnancy Between The Polycystic Ovary Syndrome And Normal Pregnant Women

Background: polycystic ovary syndrome (PCOS) is a common endocrinedisorder and metabolic abnormality disease. At present, studies have shown thatPCOS patients’ blood was in a high coagulation state,.After pregnancy,they havehigher rates of abortion, GDM and gestational hypertension disease than normalpregnant women, probably it is related to the body’s blood coagulation andfibrinolytic state. Both the pregnancy and obesity can lead to the changes of thebody’s blood coagulation and fibrinolysis state. Preliminary research shows thatduring the first trimester of pregnancy, the coagulation and fibrinolysis system isdifferent to the healthy women.Pregnant women who are obese, are observed tobe in a more prohemostatic state during the first trimester[1].Objective:As one of the series research, we want to compare the characteristics ofcoagulation and fibrinolytic markers in the third trimester of pregnancy(≥37weeks) between the polycystic ovary syndrome (PCOS) and normal pregnantwomen. And we also want to explore the effect of obesity to coagulation andfibrinolysis system in the third trimester of pregnancy between patients withPCOS and healthy women.Methods:We selected80pregnant women who visited the Outpatient Departmentof Obstetrics and Gynecology, NGH of Chinese PLA, from April2012to March2013. They were divided into PCOS pregnant group (n=40) and normal pregnantgroup (n=40). Their coagulation and fibrinolytic markers were detected during thethird trimester, just like the levels of FⅧ,FX, vWF,PAI-1,t-PA and D-dimer.Then the coagulation and fibrinolytic indices were compared between the obeseand non-obese group, so as to explore the effect of obesity to coagulation and fibrinolysis system in the third trimester of pregnancy between patients withPCOS and healthy women.Results:The activity of FⅧ and FX,vWF,PAI-1,D-dimer were significantlyhigher in PCOS pregnant group than in normal pregnant group (P＜0.05).t-PAwere significantly lower in PCOS pregnant group(P＜0.05).After the adjustment of age, in the obesity groups of PCOS, F Ⅷ activityand FX activity, vWF and PAI-1were significantly higher compared withnon-obesity pregnant women with PCOS (P <0.05), t-PA decreased obviously,the difference was statistically significant (P <0.05); F Ⅷ activity and FX activity,vWF, PAI-1and D-dimer were significantly higher compared with obesitypregnant women (P <0.05), t-PA decreased obviously, the difference wasstatistically significant (P <0.05);After the adjustment of age, in the non-obesity groups of PCOS, F Ⅷactivity and FX activity, vWF, PAI-1and D-dimer were significantly highercompared with non-obesity pregnant women (P <0.05), t-PA decreasedobviously, the difference was statistically significant (P <0.05); in the obesitypregnant women group, vWF D-dimer were significantly higher compared withnon-obesity pregnant women (P <0.05);Conclusion:Compare to the normal pregnant women, the level of coagulation ismuch higher in the third trimester of pregnancy of the polycystic ovarysyndrome；meanwhile the level of fibrinolytic is much lower. F Ⅷand FX activity,vWF can accurately reflect the status of the body’s blood coagulate conditiong, D-D dimer, t-PA and PAI1can accurately reflect the fibrinolytic condition of thebody.In the PCOS pregnancy group,obesity increased this state; Regardless of thePCOS,obesity itself is also a important factor which affect the state of bloodcoagulation and fibrinolytic system. And the PCOS’s affect to the body’scoagulation and fibrinolytic state is greater than the influence of obesity.