Discussion Of The Role Of Coagulation - Fibrinolysis System In Pregnancy-induced Hypertension Coagulation Disorder Mechanism

Objective To investigate the role of coagulation and fibrinolysis in the pathogenesis of pregnancy induced hypertention (PIH), as well as evaluat the useful screening test for Pre-DIC. Mothords Four groups of women were enrolled : 40 normal non-pregnant women,120 normal pregnancy followed longitudinally from 12-40 weeks, 50 patients with PIH including 20 mild PIH, 20 moderate PIH and 10 preeclampsia, 26 three days after delivery with PIH, TAT, AT-III, D-dimer were measured by enzyme linked immunosorbent assay(ELISA) technique. Result (1) The plasma levels of TAT in normal pragnancy were significantly higher than those in non-pregnancy(p<0.05).The levels in moderate and preeclampsia were significantly higher than those in mild (p<0.01, p<0.01) , while three days after delivery there was a decrease. (2) The plasma levels of AT-III in normal pregnancy were lower than those in non-pregnancy(p<0.05). There were significantly lower in mild, moderate and preeclampsia (p<0.05, p<0.05, p<0.05), while three days after delivery there was an increase . (3) The plasma levels of D-dimer in normal pregnancy were higher than those in non-pregnancy (p<0.01). There were significantly higher in moderate and preeclampsia (p<0.01, p<0.01), while three days after delivery there was obviously higher than those in normal pregnancy(p<0.05,p<0.05). Conclution Pregnancy is a hypercoagulable state. Enhance activation of coagulation was observed together with raised fibrinolysis in PIH. However, in preeclampsia an imbalance in the coagulation-fibrinolysis equilibrium which favours fibrin deposition. TAT and D-dimer are sensitive markers and useful screening test for Pre-DIC. Determination of plasma TAT,AT-III, D-dimer levels in secondand and third trimester pregnant women was of great significance in diagnosing early PIH and predicting the pregnosis of PIH.