Experimental Study Of Dahuang Huanglian Xiexin Decoction On The Antihypertensive Mechanism Of Spontaneous Hypertensive Rats

Objective: Of Chinese medicine in the treatment of hypertension is mainlyembodied in the unilateral cases timely research，While，The classcialprescriptions Treatment reported less，Daihuang Huanglian xiexin decoctionas zhongjing classcial prescriptions，For hypertension of suffered liver fireflaming Particularly appropriate. In combination with TCM theory and clinicalcases，Early hypertension says，liver fire flaming in the disease occurrence，development and outcome of great significance，subdue pathogenic fire in liveris positive rule method for liver-fire syndrome.Establish Daihuang Huanglianxiexin decoction on the basic formulas of the experiment.Observe theirantihypertensive effect of spontaneously hypertensive rats and to explore itscharacteristics and mechanism of action，In order to dig ancient medicine，Play classcial prescriptions curative effect by the party，In order to Providewider dialectical thinking for clinical treatment of high blood pressure.Methods:Adopt the internationally used of pathology in spontaneouslyhypertensive rats (SHR)model.he experiment is divided into Normal group(Wistar）rats，model control group，bezoar step-down pills group and DaihuangHuanglian xiexin decoction group.SHR lavage，observe their antihypertensiveeffect；Detect AngⅡ、 ET、NO and TNF alpha indicator；Through the thoracicaorta of SHR aorta paraffin，heart and kidney，HE staining，observed by opticalmicroscope， AO-multi-function microscope photos， observation oncardiovascular，renal，the influence of the thoracic aorta tissue morphology.Results: His own good antihypertensive effect，osing compared before and afterthe blood pressure significantly decreased (P <0.05)，can improve the levelsof NO，and adjust the balance of ET/NO，regulate vasoconstriction，reduce bloodvessel tension；To reduce the effect of concentration of plasma AngII and TNFa，has a good reversal SHR blood vessels、kidney、heart damage.Conclusion: His own good antihypertensive effect on SHR rats，Suffered fromthe Angle of the experimental system of the rationality and feasibility ofhypertension treatment on inflammatory type；For the clinical treatment of hypertension and hypertension combined viscera damage protection play a bigrole.