| Objective: Hashimoto’s thyroiditis(HT) is an autoimmune disease characterized indiffuse lymphoplasmacytic infiltration. It’s the most common cause of goiterhypothyroidism. Thyroid carcinoma is a common malignancy of the neck which has thehighest prevalence rate of the head and neck cancer. Papillary thyroid carcinoma(PTC)accounts for the vast majority of thyroid cancer, about80%. Hashimoto’s thyroiditiscould coexisted with papillary thyroid carcinoma, and in recent years, the incidence rateof HT coexisted with PTC was gradually rising. Both thyroid stimulating hormonereceptor(TSHR) and sodium/iodide symporter(NIS) mainly distributed on thyroidfollicular epithelial cell membrane. TSHR was the main receptor which could regulatethe growth and differentiation of throid cell.NIS could mediate extracellular iodide ionactive transport into the thyroid follicular cells. It’s a key step in the synthesis of thyroidhormones. TSHR and NIS were closely related to changes in thyroid disease.Our studywas to investigate the expressions of TSHR and NIS in HT complicated with PTC,evaluate the clinical pathological parameters such as patients’ age, sex, tumor size,lymph node metastasis and histological grading between HT coexisted with PTC andPTC.Methods:86patients underwent surgical treatment of patients with thyroid disease,including HT, PTC both25cases, HT combined PTC and thyroid adenoma both18cases.Detect the expressions of TSHR and NIS in these samples by immunohistochemicaltechnique. And the patients’ age, sex, tumor size, lymph node metastasis andhistological grading were analyzed respectively in HT coexisted with PTC and PTC group.Results:①There is a significant difference among these4groups in expressions ofboth NIS and TSHR（p<0.01）. The positive rate of expressions of TSHR in thyroidadenoma, HT, HT combined PTC and PTC group were33.33%(6/18),52.00%(13/25),83.33%(15/18) and88.00%(15/25),respectively.The positive rate of expressions ofNIS in the four groups were:27.78%(5/18),80.00%(20/25),88.89%(16/18),92.00%(23/25),respectively.②The expressions of both TSHR and NIS of PTC and PTCcoexisted with HT tissues is higher than those of thyroid adenoma tissues(p<0.01),whilebetween the them there is no significant difference.③The expression of TSHR and NISin HT is higher than normal group,the difference is statistically significant (p<0.05).④NIS and TSHR in HT with PTC and PTC don’t distributed on cell membranes only,but mainly distributed in the cytoplasm---non-functional orientation.⑤There is nosignificant difference between PTC complicated with HT and PTC group in variousclinical pathological parameters（p>0.05）.Conclusion:①High expression of TSHR and NIS were closely related to theoccurrence and development of PTC complicated with HT, which might be an early signof PTC complicated with HT;②NIS and TSHR in HT with PTC and PTC didn’tdistributed on cell membranes only, but mainly distributed in thecytoplasm---non-functional orientation,suggesting that the loss of capacity ofpolyiodides of thyroid cancer cells might have a relationship with the redistribution ofNIS;③The localization and expression levels of TSHR, NIS were closely related to thedevelopment of PTC;④HT has the same certain pathology with PTC, suggesting HTmight be a potential malignant lesions, and they are associated with each other.Weshould pay more attention and careful examination on HT;⑤There is no significantdifference between PTC complicated with HT and PTC group in various clinicalpathological parameters, suggesting that whether PTC combined with HT has nosignificant relationship with the prognosis. |
