Experience Summary On Diagnosis And Treatment Of Idiopathic Pulmonary Fibrosis Of Yanping Professor Zhang Based On Data Mining

Objective:To mine and summarize the academic experiences on diagnosis and treatment of idiopathic pulmonary fibrosis of professor Yanping Zhang, practising the use of data mining in inheriting the experiences of famous TCM doctors.Subjects:Into the object of study for the July2012-March2014visits in China academy of traditional Chinese medicine xiyuan hospital outpatient Zhang Yanping professor first diagnosis in patients with IPF, according to the inclusion criteria selected113cases meet the requirements. Methods:113cases diagnosed and treated by professor Zhang, were collected by structural clinical data collection system designed by Xiyuan Hospital of China Academy of Chinese Medical Sciences. Data mining methods such as descriptive statistics, association rules, cluster analysis were used to mine the distribution of syndrome elements, relations of diseases, syndromes and Chinese medicinal herbs, compatibility law of traditional Chinese medicine. Finally, the academic experiences on diagnosis and treatment of IPF of professor Yanping Zhang were summerised by human-computer cooperation.Results:1.The main clinical manifestations:By professor zhang in the diagnosis and treatment of113patients with IPF, mining results reveal that the progressive dyspnea, activity out of suppress, shortness of breath, tired after fatigue, cough, cough up phlegm as the main clinical symptoms, accompanied by other symptoms for stay pharyngeal foreign body sensation, dry mouth, frequent urination, like drinking water, poor shit viscous, constipation, poor sleep, sweating, abdominal distension, cough enuresis, anti acid, etc.Abnormal tongue mainly of dark red tongue, accounting for58.4%, followed by red tongue,30.1%;Moss yellow greasy is22.1%, white greasy moss is20.4%.Abnormal pulse condition for pulse slip and pulse string, its constituent ratio was42.5%and29.2%.2.syndrome of TCM:IPF main syndrome of phlegm and blood stasis resistance collaterals syndrome, qi and Yin deficiency, qi deficiency and blood stasis syndrome, lung collaterals bizu lung syndrome, phlegm heat, phlegm wet yun yu lung and lungs and spleen deficiency syndrome, its constituent ratio respectively:78.8%,65.5%,58.4%,46.9%,24.8%,20.4%,15.0%.3.Choose the clinical:Using127taste TCM, the top25in the order:rhodiola, rotary compound flowers, the sea pumice, rhizoma zedoariae, triangular, red kojic rice, radix scutellariae, astragalus membranaceus, poria cocos, phlegm, licorice, radix stemonae, radix rehmanniae, zhejiang fritillary, pinellia, radix peucedani, radix platycodi, radix ophiopogonis, Fried atractylodes, dried tangerine or orange peel, coix seed, radix clematidis, dangshen, fructus and yam, their cores took a prescription medicine for inula, sea pumice, rhizoma sparganii, rhizoma zedoariae, rhodiola, red kojic rice, radix astragali, radix rehmanniae, licorice;Prescription often choose add and subtract lung fiber side and two Chen Shang;For an update with rhodiola rosea spin after flowers, sea, sea pumice and spin pumice and rhodiola root, rhizoma zedoariae and spin after flowers, rhizoma zedoariae and spin after flowers, rhizoma zedoariae and rhodiola, rhizoma sparganii and rhizoma zedoariae, etc.Medicine abnormal point mining show cuttlefish bone, sweet, and so on.4.Academic experience:Professor zhang TCM understanding of idiopathic pulmonary fibrosis:lungs kidney deficiency is the basis;Phlegm dampness, blood stasis as the main pathological factors;The pathogenesis of lung collaterals bizu for key link.Professor zhang for the treatment of IPF ideas as follows:(1) emphasizes the combination of disease and syndrome differentiation;(2) benefit lung and kidney, dispelling stasis phlegm throughout;(3) long bi lung phlegm and blood stasis, should be broken blood tong bi, soft firm fights;(4) four close and, on the basis of the tongue like change. Drug treatment to invigorate the circulation of t2dm, qi and nourishing Yin, eliminating phlegm cough as the main therapeutic treatment, phlegm and blood stasis long bi lung collaterals, tong bi should be applied to break the blood, soft firm fights medicine, at the same time complementary with spleen wet medicine, heat, etc;Good medicine for compatibility;Add and subtract medicine thought main basis and witness, symptoms change and modern pharmacological research.Conclusion:Through the clinical research of this paper may draw the following conclusion: 1.The clinical research results show that the common clinical manifestations of IPF is: after progressive dyspnea, activity out of suppress, shortness of breath, fatigue weakness, cough up phlegm, cough as the main clinical symptoms, such as with previous epidemiological survey results are basically the same.2.Through the data mining system, sorting and analyzing the clinical data, shows that phlegm and blood stasis resistance type IPF often witness collaterals syndrome, qi and Yin deficiency, qi deficiency and blood stasis syndrome, lung collaterals bizu, phlegmy wet aggregates lung, phlegm heat yu lung and spleen deficiency syndrome, lung consistent with professor zhang use drug for the treatment of IPF, commonly used medicines for promoting blood circulation to remove blood stasis and replenishing qi, nourishing Yin, eliminating phlegm, t2dm, soft firm fights, profit of lung and spleen.3.The label for this virtual to real, lung and kidney deficiency, phlegm turbidity and blood stasis of collaterals as standard, the pathogenesis of lung collaterals bizu as the key link, professor zhang using TCM blood tong bi, soft firm fights method in the treatment of IPF, can alleviate the clinical symptoms of patients.4.Application of data mining method to explore professor zhang treatment of IPF experience and the regularity of drug is feasible.