Clinical Study On Correlation Between BRAF Gene And Thyroid Papillary Carcinoma

Objective: To analyse the correlation between BRAF gene mutationand the high-risk clinicopathological features of papillary thyroid cancerand iodine uptake rate after total thyroidectomy.Methods: Retrospectively analyse patients with papillary thyroidcarcinoma from December2013to December2014in our hospital,underwent surgical treatment and BRAF mutation detection.We calculatethe mutation rate of BRAF gene and compile statistics in the relatedclinical pathologic features of patients in this group（gender, age, familyhistory, pathological subtype of papillary carcinoma, maximum diameterof carcinoma, lesion number, capasula invasion, local lymph nodemetastasis, unilateral or bilateral carcinoma, accompanied by Hashimoto’sthyroiditis or Nodular goiter or not and clinical stage）and the iodineuptake rate of the patients treated with131I after total thyroidectomy.Results: BRAF gene mutation rate is84.9%in this group whichcontains252patients with papillary thyroid carcinoma.There is nosignificant relationship between the BRAF mutation and the high-riskclinicopathological features above of the patients and iodine uptake rateafter total thyroidectomy. Conclusion:(1)In this study, the BRAF mutation rate is84.9%.(2)In this study，the BRAF mutation and the high-risk clinicopathologicalfeatures of the patients（gender, age, family history, pathological subtypeof papillary carcinoma, maximum diameter of carcinoma, lesionnumber, capasula invasion, local lymph node metastasis, unilateral orbilateral carcinoma, accompanied by Hashimoto’s thyroiditis or Nodulargoiter or not and clinical stage） and iodine uptake rate after totalthyroidectomy have no relevance.Separate detection of BRAF genemutation of papillary thyroid carcinoma makes no means to guidethe treatment of thyroid papillary carcinoma and predict theprognosis.