Role Of Contrast-enhanced Ultrasound In Follow-up After Cryoablation For Prostate Carcinoma

Objective To study the Role of Contrast-enhanced ultrasound in follow-up after cryoablation for prostate carcinoma.Methods Fifty five patients with pathologically confirmed prostate cancer underwent cryoablation, and after therapy all of them subjected to PSA analysis. Phoenix definition (nadir+2) was used to defined biochemical recurrence. Patients were received TRUS, CEUS if biochemical recurrence were detected. Use Qontraxt to analyse the interested lesions of the images after CEUS, and biopsy under the guidance of CEUS.Results:Mean patient age was73.8years (50.1-86.4), mean time of follow-up was30.8months. The total biochemical disease-free survival was67.2%(37/55).5of the18patients had recurrent prostate cancer confirmed by prostate biopsy. After CEUS,we found8perfusion abnormal lesions, of which5was prostate cancer confirmed by biopsy. PK, sharpness and AUC of the suspected lesions were greater than those of the opposite normal regions, and TP was shorter. PSA of the8patients descended significantly after second focal cryoablation.Conclusion:Our short-term follow-up suggests that cryoablation offers a safe and effective alternative for the primary treatment of localized prostate cancer and salvage treatment of locally recurrent prostate after androgen deprivation therapy. CEUS is an effective way for follow-up of prostate cancer after cryoablation, which can diagnosis residual and recurrent prostate earlier and can be used to guide the biopsy and second treatment.