Hypertension Treated From Liver And Spleen Kidney Theory And Systematic Review Of Clinical Literature

Objective:Hypertension is a traditional Chinese medicine “vertigo” and “headache” category, Understanding of the disease, that generations of physicians have discussed. According to the research of the modern subject, the occurrence of hypertension with close ties to the liver and spleen and kidney. So this article discusses from the theory of liver and spleen kidney treatment of high blood pressure, and domestic modern comprehensive retrieval from the liver and spleen kidney in the treatment of hypertension related literature. Using the method of system evaluation, analysis from the liver and spleen kidney treatment hypertension commonly used, the formulas of medicine, evaluation from the clinical curative effect of treatment of liver and spleen kidney hypertension, provide reference for clinical.Methods:Strict and exclusion criteria, through the China journal full-text database(CNKI), comprehensive retrieve published from 1995 ~ 2015 from the aspects of liver and spleen kidney clinical trials for the treatment of hypertension. Using the term "hypertension" and "liver and spleen kidney" retrieve statistics, etc. According to the literature inclusion and exclusion standard literature system evaluation, selected to meet the requirement of the literature, using RevmMan5.0 analysis software, heterogeneity on the literature analysis, According to the results of the consistency check by using the fixed effects model or random effects model for Meta analysis. The funnel figure on published sex bias is discussed.Results:1 This study was retrieved from liver and spleen kidney treatment of hypertension related with 371 references. According to the literature into and exclusion criteria, after screening the included in the Meta analysis with 80 references, a total of 4943 patients, including 16 papers from high blood pressure, liver treatment 20 treated from the spleen of high blood pressure, 14 from the kidney treatment of high blood pressure.2 Application support RevmMan5.0 for assessing the effect of treatment.2.1 From liver treatment of hypertension clinical literature on the evaluation of the system, in terms of antihypertensive effects comparison, the OR was 2.94(95% CI) [2.19, 3.94](P < 0.00001), OR in terms of symptom curative effect comparison(95% CI) was 4.37(2.84, 6.74)(P < 0.00001), the treatment of high blood pressure from hepatic differentiation of traditional Chinese medicine drugs on blood pressure changes in total effective rate and symptom improvement aspect than pure western medicine treatment the overall curative effect significantly.2.2 Treated from the spleen of clinical literature system evaluation on the hypertension, in terms of antihypertensive effects comparison, the OR was 2.94(95% CI) [2.30, 3.77](P < 0.00001); In terms of symptom curative effect comparison, the OR was 4.60(95% CI) [3.31, 6.38](P < 0.00001), treating the hypertension treated from the spleen drugs on blood pressure changes in total effective rate and symptom improvement aspect than pure western medicine treatment the overall curative effect significantly.2.3 From treatment based on renal hypertension clinical literature system evaluation, the antihypertensive efficacy of comparison, the OR was 3.86(95% CI) [2.90, 5.12](P < 0.00001), the symptom curative effect comparison, the OR was 4.58(95% CI) [3.33, 6.29](P < 0.00001), treatment based on treating the hypertension from kidney drugs on blood pressure changes in total effective rate and symptom improvement aspect than pure western medicine treatment the overall curative effect significantly.3 Drawn from the liver, spleen, kidney three dirty funnel figure for the treatment of hypertension, the results show that most data corresponding to the funnel basic symmetric figure, at the 95% confidence interval, prompt published sexual bias to get good control.Conclusions:Meta analysis of the results from the clinical curative effect of treatment of high blood pressure, liver and spleen kidney does traditional Chinese medicine treatment is better than pure western medicine western medicine. Meta analysis result is decided by various clinical problems, in chooses the literature study is mostly small randomized controlled trials, method of quality is not high also, is primarily to test is random, random method is not clear, all test did not describe the hide, because most are low quality documents, so may have a certain influence on evaluation results.