The Studies On The Correlation And The Effect Of Nutritional Status And Micro Inflammation In Patients With Maintenance Hemodialysis By Using Different Treatments

Objective : Evaluate the effect of different treatments to the effect of nutritional status and Micro inflammation in patients with maintenance hemodialysis.Methods : In this study,we choosed 60 patients who are in nutritional status, with maintenance hemodialysis during March 2012 to June 2013,they were treated in nephrology dialysis center of the Second Affiliated Hospital of Henan Institute of Traditional Chinese Medcine.We took of three different treatment intervention, the patients were randomly divided into LFHD group, HFHD group, Chinese medicine group were treated for 4 month evaluation. Evaluated respectively after treatment for second months and fourth months for Scr, BUN, beta β2-MG indices of renal function and Hb, ALB, CRP and IL-6 nutrition indicators related micro inflammatory factor.Results:1 Tests of renal function: the traditional Chinese medicine group in the long term intervention(for 4 months) after in vivo Scr, can significantly reduce the level of BUN, better than the LFHD group, HFHD group(P=0.001<0.05; P=0.005<0.05). The Chinese medicine group of beta 2-MG clearance in second, in 4 months after treatment has made significant effect, and the HFHD between the groups showed no statistical significance(P=0.53>0.05; P=0.14>0.05).2 Determination the two kinds of micro inflammatory factor: intervention treatment for second months, fourth months, the Chinese medicine group on CRP, IL-6 removal effect is better than that of HFHD group(P<0.05), and along with the time extension, this improvement seems to be more obvious.3 Nutrition index evaluation: after intervention for fourth months, group LFHD, group HFHD and group ALB, Hb than traditional Chinese medicine treatment for 2 months, 0 months, there were significant differences(P<0.05), but fourth months treatment, the Chinese medicine group is better than ALB, Hb index in LFHD group, HFHD group, there were significant differences(P=0.003<0.05;P=0.01<0.05), indicating that HFHD combined with traditional Chinese medicine enema has good regulation of ALB, Hb, can correct the malnutrition patients.4 Correlation Analysis: between inflammatory factor and nutrition indicators through multiple regression analysis, the amount of change before and after treatment ALB increased(y) and the changes of IL-6 before and after treatment decreased(x1), the changes of CRP decreased(x2) between a negative correlation, the regression equation was y=2.35-0.01x1-0.373x2; the correlation coefficient is R=0.387, F=5.02,P=0.01<0.05 regression equations of effective; significant independent variables the correlation coefficients were 0.08, 0.06, non significant correlation.Conclusion:1 The three kinds of treatment are effective to control the level of accumulated toxin in the patients with MHD,and traditional Chinese medicine group is the most effectively;2 The traditional Chinese medicine group, HFHD group can restrain the end in patients with end-stage renal disease inflammatory factor level, improve the nutritional status of the patients, and combined with traditional Chinese medicine external treatment can effectively reduce the blood micro inflammatory factor level in short time;3 Reducing the level of inflammatory factors can improve the nutritional status of patients with end-stage renal disease, but the nutritional status of patients to improve the insufficiency and related to reduce inflammatory factors.