A Prospective, Single-center, Randomized Controlled Clinical Study On The Treatment Of Maintenance Hemodialysis Malnutrition With Reconciliation Method

Background:Along with the development of hemodialysis,morbidity of maintenance hemodialysis patients increased year by year,besides survival time prolonged gradually.Therefore,to find a new effective method that can imporove the qualities of life in the MHD patients has been became the focus of clinical studies.The malnutrition is one of the most common complication in MHD patients.The clinical features of malnutrition is the inbalance of nutrient.Malnutrition is the independent risk factor of mortality,hospitalization,cardiac events and quality of life,thus the treatment of malnutrition had been paid attention of scholoars at home and abroad.Unfortunately,improving nutritional status remains a troublesome clinical problem,with western treatment having little impact on disease.Therefore,research of improving nutritional status with Traditional Chinese Medicine have clinical values.This study is focused on estimating the efficiency and safety of harmonizing therapy on MHD patients with PEW and devlope to provide new therapy on malnutrition.Objectives:The aim of this study was to evaluate the clinical safety and efficacy of "harmonizing"therapy on maintenance hemodialysis(MHD)patients with PEW.Methods:This is a 24-weeks,single-centered,prospective and open,randomized controlled trials.50 cases of MHD patients in the Guanganmen hospital from September 2000 to March 2018.The groups were divided by random figure table into experimental group(n=25)and control group(n=25).Under the control of supplement and treatment,the experimental group were supplied YiQiJiangZhuoJiaJian Qd with Carnitine 10ml iv 3 times a week.The control group were supplied only Carnitine 10ml iv 3 times a week.Collect symptom grading quantification score-assessing method,Nutrition status etc to estimate the YiQiJiangZhuoJiaJian of clinical safety and efficiency.Results:The results of therapeutic appraisal1.Comparison of gender,age,disease between two groups before treatment,and found no statiscally significant(P>0.05).2.Compare the anthropometry between two groups:the triceps of experimental groups significantly improved(P<0.05).Other index found no difference(P>0.05).Between tfference after treatment(P>0.05)3.Compare the nutrition status betwwen two groups:both of two groups had significant decreased in Alb(P<0.05).Though after the treatment Alb had significant difference between two groups.Both of groups all had decrease of tumor necrosis ?(P<0.05),But there are no statistically significant between two of them.Any other of experimental index had no significant difference after treatment(P>0.05)4.Compare the Objective Score of Nutrition Dialysis(OSND):After treatment,the OSND of experimental group statistically increased(P<0.05),though control group was not(P>0.05)Also there were no statistically difference between two of groups(P>0.05).Comparing the level of score between two of groups,we found that the experimental groups improve the nutritional status more than the control group(P<0.05).5.Compare the symptom grading quantification score-assessing:Both of groups significant relived after treatment(P<0.05),but there were no statistically significant between two of them(P>0.05).Both of groups significantly relieved the symptoms include languished,anorexia,thirst,constipation.The experimental group significantly relieved nausea(P<0.05)After 24-week-treatment,clinical symptom effective percentage was 60%,although the control group was merely 44%.Between two of them,there were no statistically significant(P=0.531,P>0.05)Result of safety appraisal:1.There were no statistically significan between two fo groups on experimental index(P>0.05)2.Both of groups didn't happen Adverse drug reaction.There were no significantly difference(P>0.05).Conclusion:1.YiqiQingZhuoJiaJian had certain effects to improve malnutrition status in some ways,include decreased TNF-?,delayed Albumin decreased,increased OSND.2.YiQiQingZhuoJiaJIan had certain effects in improving relieving clinical symptoms of MHD with malnutrition patients.3.YiQiQingZhuoJiaJian was safe in clinical treatment.