A Correlation Study Between Nodular Goiter And Tcm Type And Investigate The Relationship Nodular Goiter And Urine Iodine

Objective : Through clinical observation, distribution of urinary iodine research nodular goiter patients, on the basis of analysis of the correlation of thyroid function in patients with nodular goiter, ultrasonography and urinary iodine features, and explore different TCM syndromes and urinary iodine the relationship between thyroid function and thyroid morphology, as nodular goiter syndrome differentiation theory provides a theoretical basis for individualized patient treatment and guidance iodine.Methods: In accordance with generally accepted diagnostic criteria, inclusion and exclusion criteria to develop, collect 98 cases of nodular goiter patients, detect urinary iodine(UI), three free triiodothyronine(FT3), free thyroxine(FT4), high sensitivity and promote thyroid hormone(s TSH), thyroglobulin antibody(TGAb), thyroid peroxidase antibody(TPOAb) and thyroid ultrasound. Standards are divided according to urinary iodine iodine deficiency, iodine amount, more than adequate iodine and iodine excess four groups, the above analysis and urinary iodine observed indicators of relevance. Then type in patients with TCM diagnostic criteria are divided into qi phlegm, phlegm, Yin Tanning, Yang contact resistance IV and correlation analysis and observed.Results:(1)In all cases, a sufficient amount of iodine over the highest proportion(42.8%), iodine amount(29.5%) and iodineexcess(21.6%), followed by iodine(6.1%) at least; female prevalence was significantly higher than men the average age of each group of urinary iodine was no significant difference(p>0.05).(2)Each urine iodine group FT3, FT4 levels no statistically significant difference(p>0.05); iodine excess group TSH levels higher than the other three groups, more than adequate iodine group and iodine excess groups TGAb and TPOAb positive rate was significantly higher than the other two groups, there is a statistically significant difference(p<0.01).(3)Nodule detection rate with the increase of urinary iodine levels increased more hair, excess iodine group multiple nodules detection rate was significantly higher than the other three groups(p <0.05); echo nodules in anechoic and hypoechoic share the highest proportion, respectively, accounted for 39.8% and 21.4% of the total cases; nodules demarcated the right amount of iodine group was higher than the proportion of the other three groups were significantly different(p<0.05), calcified nodules and blood groups constituted no statistically significant difference compared(p>0.05).(4)The maximum diameter of the nodule to a maximum of 10 ~ 19.9mm; each group, the group constitutes the right amount of iodine and iodine excess nodule size group differences(p<0.05) than with respect to iodine deficiency and iodine than adequate group, where the right amount of iodine group to 10~19.9mm nodules common, iodine excess groups to>20mm nodules common.(5)TCM types nodular goiter patients with phlegm-based, accounting for 38.8% of cases, followed by qi phlegm type(27.5%); the average age of patients with Yang contact resistance is higherthan the other three groups(p<0.05), phlegm average duration was significantly higher than the other three groups; each group, Yang contact resistance type of urinary iodine than the other three groups constitute a significant difference(p<0.05), and urinary iodine median(221.2μg / L) was significantly higher than the other three syndromes.(6)Each type of TCM, Yang contact resistance type TSH and TPOAb level was higher than the other three groups(p<0.05), FT3, FT4 levels lower than the other three groups(p<0.05); TSH deficiency and Phlegm lower than the other three groups(p<0.05); the positive rate in each group TGAb no significant difference(p>0.05); goiter series no significant difference between groups(p>0.05).Conclusion: In the treatment of patients with iodine deficiency has been relatively rare, the majority of urinary iodine level in more than adequate, with the increase iodine intake can increase the incidence of nodular goiter, when the UI> 200 when will affect thyroid function. The level of urinary iodine also have relevant effects on thyroid nodule morphology, size and echo. In Chinese medicine syndromes in patients with nodular goiter main phlegm, qi phlegm followed; also found that patients with Yang contact resistance of urinary iodine levels higher than other syndromes, and FT3, FT4, TSH levels and positive TPOAb rate compared with other syndromes also have differences.