The Effect Of Strengthing Spleen,nourishing Kidney And Activating Circulation Prescription On Peripheral Blood Epcs Content Of The Patients With Cerebral Infarction At Convalescence

Objective:Taking the patients with cerebral infarction at convalescence(the type of deficiency of spleen and kidney)as the research object,to compare the changes before and after the treatment about the TCM syndromes’ score,the NIHSS scale,the MBI scale. To further confirm the clinical curative effect of the treatment of cerebral infarction at convalescence(the type of deficiency of spleen and kidney) by the method of supporting the healthy energy. The levels of peripheral blood endothelial progenitor cells(EPCs) of all the patients were determined before and after the treatment,and to explore the influence of strengthing spleen, nourishing kidney and activating circulation prescription on those,and study the mechanism on cerebral infarction.Methods: This study successively admitted patients with cerebral infarction at convalescence(the type of deficiency of spleen and kidney).72 patients meeting the criteria were divided into 2 groups at random:the treatment group and the control group,36 cases in each group. Treatment group employed basic treatment plus strengthing spleen, nourishing kidney and activating circulation prescription,the total of continuous treatment for 14 days. Level of circulating EPCs coming from venous blood,the surface makers CD34+/KDR+ /CD133 were examined using flow cytometry. Both groups were evaluated with the TCM syndromes’ score,the NIHSS scale,and MBI scale at the beginning and the end of the treatment.Results: 1 14 days later,the level of EPCs were obviously improved in comparison with those before treatment in both groups,there was statistically significant(P=0. 001,P<0. 05); the treatment group was improved more obviously than the controlgroup and the difference was statistically significant(P=0. 016,P<0. 05). 2 14 days later, the TCM syndromes’ score were obviously declined in comparison with those before treatment in both groups, there was statistically significant(P=0. 001,P<0. 05); the treatment group was declined more obviously than the control group and the difference was statistically significant(P=0. 039,P<0. 05). 3 14 days later,the NIHSS scale score were obviously descended in comparison with those before treatment in both groups,there was statistically significant(P=0. 001,P<0. 05); the treatment group was descended more obviously than the control group and the difference was statistically significant(P=0. 001,P<0. 05). 4 14 days later,the MBI score were obviously boosted in comparison with those before treatment in both groups, there was statistically significant(P=0. 001,P< 0. 05); the treatment group was boosted more obviously than the control group and the difference was statistically significant(P=0. 001,P<0. 05).Conclusion: There are significant therapeutic effects of the strengthening spleen nourishing kidney and activating circulation prescription on patients with cerebral infarction at convalescence(the type of deficiency of spleen and kidney), such as improving circulating endothelial progenitor cells,the TCM syndromes and the activities of daily living of patients, at the same time declining NIHSS scale score,it can be seen that the strengthening spleen nourishing kidney and activating circulation prescription efficacy is better than the basic treatment. Preliminary discussion that the probable mechanism of significant therapeutic is mobilizing EPCs in the bone marrow to migrate into the blood and homing to damaged tissue at cerebral infarction, therefore boosting repair of damaged blood vessels and angiogenesis of infarct region,Yet it need a further investigation..