Analysis On The Influence Of Uygur Sand Therapy On Knee Osteoarthritis Of Rabbit Femur Bone Volume Mechanical Properties

Uighur medicine’s sand theray is a kind of old medical skill; it can be used to remedy joint disease assistantly, and has special curative effect on osteoarthritis. Under the achievement of predecessors, this article combines animal experiment, applies relative software to analysis the influence of sand therapy on the changes the femur mechanical properties of osteoarthritis. And then I take advantages of Finite Element Analysis Method, advance the article to a new theoretical level, in order to extract and purify a scientific, refined, universal research result, and refer scientific theory to subsequent researchers.At first, my article will determine the effect of the different sand therapy stage on the changes the femur mechanical properties of osteoarthritis in rabbits in treatment. Methods as follows: 30 New Zealand rabbits were randomly divided into three different groups. The first group was designed to be not sand therapy pathological group(n=10). The second group was designed to be sand therapy pathological group treated for 15 d(n=10). The third group was designed to be sand therapy pathological group treated for 25 d(n=10).The second and third group was executed sand therapy 30 min daily. 0.3 ml/kg 3% Papain were injected into the joint space of right knee of the three groups on the 1st, 5th and 12 th respectively, to establish osteoarthritis models(model group); the left legs were used as the normal control group. Vivo CT scans were performed, then CT data imported into MIMICS software, the femur model was extracted in the MIMICS software and morphologically measure middle bone cross-section data. Right and left femurs of three groups were taken as specimen. The tree-point bending test were performed, the load-deflection curves were obtained and extract elastic deflection and elastic bending strength. Finally, bone basic mechanical properties were calculated. Then I get the results: The first group assessed as middle OA, The second group assessed as middle OA, The third group assessed as early OA. Compared with normal control group, the inertia moment of femur in model group had on significant changes(p> 0.05); But the elastic load, stress, strain, elastic modulus, deflection, stiffness coefficient and structure toughness were greatly decreased, and structure stiffness were greatly increased(p<0.05). Compared among groups, strain, elastic modulus, inertia moment, stiffness coefficient had significant discrepancies(p<0.05). The elastic load, stress, deflection, structure toughness, structure stiffness had on significant discrepancies(p<0.05).So I drew a conclusion like this: The mechanical properties of the rabbit femur with osteoarthritis were significantly decreased; The mechanical properties of the rabbit femur with sand therapy were significantly increased. The different sand therapy stage has a different efficacy on osteoarthritis.Second, this topic is committed to explore a kind of nonuniform isotropic finite element modeling of femur which is based on CT values, and applied it in the effect of Uygur sand therapy on the mechanical properties of rabbit femur. The Methods as follows :Establish osteoarthritis model of right posterior of 8 adult New Zealand rabbits and divide them into sand therapy group and control group. Femurs of rabbits are scanned by CT, import the topographic image data into Interactive medical image control system(MIMICS), separate and generate a 3D model of the femur, do volumetric mesh of the 3D model combining with ANSYS APDL command flow, Then import the LIS format files of volume mesh into MIMICS to assign material properties, finally, simulate and solve the three-point bending test in Ansys, contrast and analysis the results. Results :Established a nonuniform isotropic three-dimensional finite element model of femur, the deflection, effective stress which obtained from simulation analysis and experimental data have good correlation(rdeflection=0.932,rmaximum stress=0.942).Conclusion :In this paper, the finite element modeling method is more in line with the structure and material properties of bone, and it can be used for bone stress and deformation analysis. Provide scientific and useful basis for applying it into sand therapy and other field of rehabilitation research.