The Expression Of FOXM1 In Carcinoma Of Urinary Bladder And Its Clinical Implications

Objective: Through the detection of transcription factor FOXM1 in bladder cancer, carcinoma of urinary bladder) expression in the organization, and analysis of the relationship between its expression and clinical pathological parameters.Methods: Using RT-PCR method to detect FOXM1 in 40 cases of patients with bladder tumor tissues and matched m RNA expression in normal bladder tissues;Adopt the method of immunohistochemical detection of 40 cases of paraffin embedding in bladder cancer tissues and matched normal bladder tissue protein expression levels and parts;Further using western blot method to detect 40 pairs of FOXM1 expression in bladder cancer tissues and normal bladder tissues.Results: Transcription factors FOXM1 m RNA in bladder cancer tissue is significantly higher than the relative expression of paired normal bladder tissues, difference was statistically significant(rank and inspection, P = 0.025);FOXM1 protein expression in bladder cancer tissue of the positive rate was 88%(35/40), while in pairs for lower expression in normal bladder tissues or not expression, including the positioning organization and expression of cytoplasm and nuclei, the difference was statistically significant(p < 0.01);FOXM1 protein expression level of performance for the higher grade of bladder cancer tissues was higher than low grade of bladder cancer group, the expression of the difference was statistically significant.Conclusion: This experimental study show that transcription factors FOXM1 in bladder cancer tissue increased, and the grading, staging, invasion and metastasis of tumor, etc, and there were some correlations in patients with clinical pathological characteristics.Analysis of the expression of FOXM1 situation may help us comprehensive judging the prognosis of patients with bladder cancer, and may have a potential target for bladder cancer therapy.