Hepatocellular Carcinoma CT Performance Compared With Surgical Pathology And Its Relationship With Vascular Endothelial Growth Factor And Prognosis

Objective: to study the HCC(Hepatocellular Carcinoma, HCC) CT performance compared with postoperative pathology, Vascular Endothelial Growth Factor(Vascular Endothelial Growth Factor, VEGF) expression and its prognosis, in order to further understand the significance of CT signs of HCC, for preoperative noninvasive diagnosis, prognosis, and provides more reasonable reference for the treatment of choice.Method: collecting 75 cases of HCC patients, preoperative CT scan and enhanced scan,postoperative pathological specimens for paraffin embedding, biopsy, conventional HE staining,and using immunohistochemical staining of S- P method, detecting the VEGF protein expression.The CT manifestation of HCC compared with surgical pathology, and statistical analysis of CT can see with the relationship between VEGF and outcome.Results:1. 75 patients with HCC, preoperative CT of tumor necrosis, cirrhosis of the liver and lymph node enlargement and the surgical pathology can see difference was statistically significant(P <0.05);While HCC tumor diameter, portal vein and hepatic vein tumor emboli CT performance similar to those seen in a surgical pathology, there was no statistically significant difference(P >0.05).2. psuedocapsule of HCC, tumor size, pathological blood vessel, tumor necrosis and VEGF expression between the difference was statistically significant(P < 0.05);HCC of portal vein and hepatic vein tumor emboli, cirrhosis of the liver and intrahepatic lesions(single or multiple),lymph node enlargement, and there was no statistically significant difference between VEGF expression(P > 0.05).3.HCC recurrence or metastasis associated with VEGF expression, the difference was statistically significant(P < 0.05).4.CT signs of psuedocapsule, tumor length to diameter, portal vein and hepatic vein tumor emboli, cirrhosis of the liver lesions(single or multiple) associated with prognosis(recurrence or metastasis), the difference was statistically significant(P < 0.05), while the pathological blood vessel, tumor necrosis and lymph node enlargement has nothing to do with the prognosis,recurrence or metastasis(P > 0.05).Conclusion: the CT manifestations and the VEGF expression and prognosis of HCC(recurrence or metastasis) is closely related to CT signs although most can reflect the pathological and biological characteristics of HCC, but there are still some limitations.