Association Analysis Of Endothelial Nitric Oxide Synthase Gene Polymorphism And Myocardial Infarction In Uygur

Objective : To investigate the relationship between polymorphisms of endothelial nitric oxide synthase(e NOS) gene(rs41377046、rs184329901 and rs369082701) and myocardial infarction(MI) in Uygur.Methods : Select in Mar. 2012- Dec. 2014 in the cardiovascular department of Xinjiang Uygur Autonomous Region People’s Hospital of 576 patients. All examined patients underwent coronary angiography. MI group in Uygur including 139 patients whose average age was 56.77±10.03, MI group in Han including 157 patients whose average age was 59.63±9.97. Meanwhile, the patients undergoing coronary angiography without any artery lesions were as control group, control group in Uygur including159 patients whose average age was 55.63±10.07,control group in Han including 121 patients whose average age was 58.07±11.04. Polymorphisms of endothelial nitric oxide synthase gene,rs41377046,rs184329901 and rs369082701,were identified in 576 patients by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry(MALDI-TOF-MS).Results:(1)For the rs41377046 polymorphism, there was significant difference in the frequencies of the genotypes and alleles between MI cases and controls in Uygur(P < 0.05). Frequencies of rs41377046AA/AG genotype and A allele were 25.1% and 13.3% in MI group respectively, which were higher than those in control group(10.7% and 5.6%, respectively, P<0.05). And there was significant difference in the frequencies of the genotypes and alleles between MI cases and controls in Han(P<0.05). Frequencies of rs41377046 AA/AG genotype and A allele were 20.3% and 11.1% in MI group respectively, which were higher than those in control group(9.0% and 4.9%, respectively, P<0.05).(2)For the rs184329901 polymorphism, there was no significant difference in the frequencies of the genotypes and alleles between MI cases and controls in Uygur(P > 0.05). But there was significant difference in the frequencies of the genotypes and alleles between MI cases and controls in Han(P<0.05).Frequencies of rs41377046 CT/TT genotype and T allele were 31.3% and 17.8% in MI group respectively,which were higher than those in control group(20.7% and 11.2%, respectively, P<0.05).(3)For the rs369082701 polymorphism, there was no significant difference in the frequencies of the genotypes and alleles between MI cases and controls in Uygur(P >0.05). And there was no significant difference in the frequencies of the genotypes and alleles between MI cases and controls in Han(P>0.05).(4)After risk analysis,individuals with AG and GG genotypes of rs41377046 had 1.031 and 0.366 times higher risks to develop MI than those with AA genotype respectively, while individuals with G allele had0.461 times higher risk to develop MI than those with A allele.Conclusion:(1) The e NOS gene of rs41377046 may be associated with MI in Uygur, individuals with A allele at rs41377046 of e NOS gene are at higher risk of MI.(2) Polymorphism of rs184329901 and rs369082701 may be irrelevant with MI in the Uygur.