Association Study Of Alu Repeat Insertion/deletion Polymorphism In Tissue Plasminogen Activator Gene And The Glu-Asp298 Mutation At Exon 7 Of The Endothelial Nitric Oxide Synthase Gene With Myocardial Infarction

Cardiovascular disease is a multifactorial disease that involves atherosclerotic and thrombotic factors. Its occurrence and development are the results of interactions between a variety of genetic factors and environmental conditions. Researches of the genetic factors will be helpful to understand the molecular mechanisms for atherogenesis. Genetic polymorphisms have been associated with myocardial infarction(MI) and angina pectoris.Tissue plasminogen activator(t-PA) is a key enzyme in regulation of the fibrinolytic system. Furthermore, the impairment of the fibrinolytic capacity is one of the risk factors in MI. Alu repeat insertion/deletion polymorphism in intron h of tissue plasminogen activator gene was observed to be related with MI. There have been some conflicted results. We studied the association of this polymorphism in t-PA gene with the...