| Objective:Through a lot of reading literature and HR-HPV were retrospectively analyzed negative cervical intraepithelial neoplasia and cervical cancer patients with clinical data, analyze the HR-HPV negative because the hair cause of disease in patients with cervical lesions,analyzed HR-HPV negative and HR-HPV positive patients with cervical lesions in the liquid based cytology results and cervical postoperative pathologic results. Cervical liquid based cytology comparative analysis results for the patients with ASCUS and ASC-H, HR-HPV testing results and the stratification of age, pregnant time and production time, the relationship between cervical pathological results and other related factors, and discusses the probability of such highly level in patients with cervical lesions with HR-correlation of HPV detection results, comparison and draw relevant conclusions, for different types of cervical cancer to provide new clinical individual therapy.Methods:Retrospective analysis of 207 cases of HR-HPV negative and HR-HPV positive cervical intraepithelial neoplasia and cervical cancer patients with clinical data, and carries on the reasonable group discussion, using SPSS18.0 software package for statistical analysis. :difference was statistically significant(P < 0.05).Results:1. 207 patients with cervical intraepithelial neoplasia and canceration, HR-HPV positive for 179 cases(86.47%), HR-HPV negatie 28 cases(13.53%), both have significant differences. Postoperative pathological results for CIN Ⅰ 20 cases(9.66%), including HR-HPV negatie 8 cases(40.00%), HR-HPV positive for 12 cases(60.00%),. CINⅡ15 cases(7.25%), including HR-HPV negatie 4 cases(26.67%), and HR-HPV positive for 11 cases(73.33%). CINⅢ80 cases(38.65%), including HR-HPV negatie 8 cases(10.00%), HR-HPV positive for 72 cases(90.00%). SCC of 92 cases(44.44%), including HR-HPV negatie 8cases(8.70%), HR-HPV positive for 84 cases(91.30%). Through SPSS18.0 statistical software, P = 0.0039(P < 0.05), the difference is statistically significant.2. 20 cases of cervical pathological results for low level cervical intraepithelial neoplasia(CINⅠ) of the patients, HR-HPV negatie 8 cases(28.57%), HR-HPV positive for 12 cases(6.70%). 187 cases of cervical pathological results for high level cervical intraepithelial neoplasia(CINⅡ, CINⅢ) and cancerous patients, HR-HPV negatie 20 cases(71.43%), HRHPV positive for 167 cases(93.30%). Through SPSS18.0 statistical software, P = 0.0010(P <0.05), the difference is statistically significant.3. 61 cases of cervical liquid based cytology for the patients with ASCUS and ASC-H,HR-HPV negatie in 7 cases(11.48%), HPV positive for 54 cases(88.52%), and compare the two cervical pathological results for high level of lesion and the probability of cancer,HR-HPV negatie for 6 cases(85.71%), HR-HPV positive for 50 cases(92.59%), by SPSS18.0 statistical software, P = 0.4684(P < 0.05), there was no statistically significant difference.4. Through statistical analysis of pregnant time and production time for HR-single factor influence of HPV infection, pregnant time and HR-HPV infection correlation coefficient was0.3035, P < 0.0001, and HR-HPV infection correlation was statistically significant. Of time production and HR-HPV infection of the correlation coefficient is 0.3374, P < 0.0001, the correlation between HPV infection and have statistical significance.5. 61 cases of cervical liquid based cytology results for the patients with ASCUS and ASC-H, HR-HPV negative patients at an average age of 46.1429 years, median age was 49,minimum age of 25, the largest age was 64 years old. HR-HPV positive patients with an average age of 45.5556 years, the median age of 45, minimum age is 23 years old, biggest age was 88 years old. Through the SPSS18.0 statistical software, normality test, age is normal distribution. Using the T test. T = 0.14, P = 0.14(P > 0.05), two groups there was no statistically significant difference ages.6. Comparative analysis of 92 cases of cervical cancer patients with HR-HPV positive people and HR-HPV negatie in all kinds of risk factors, using chi-square analysis contrast,due to objective factors such as sample size limit, no statistically significant difference were observed in the various risk factors comparison.Conclusion:1. HR-HPV is known to cause cervical intraepithelial neoplasia and canceration of the main pathogenic factors. HR-HPV negative cervical intraepithelial neoplasia and cervical cancer, it can be caused by a variety of reasons, the number while a minority, but meaning cannot be neglected.2. Cervical liquid based cytology results for the patients with ASCUS and ASC-H,HR-HPV negative patients may also be high level cervical lesions and cancer, its probability and HR-HPV was no difference.3. HPV infection is affected by many factors, there is a clear positive correlation with maternal times, with the increase of maternal time, the risk of HPV infection is on the rise.4. The cervical liquid based cytology results for the patients with ASCUS and ASC-H,HR-HPV negative- high level cervical lesions and cancer patient age and HR-HPV was no obvious difference.5. This study suggests that HR- although the cervical HPV negative Numbers in the minority, but still exists objectively, cannot be ignored. But with the HR-HPV positive patients with cervical cancer there were no significant difference in all kinds of risk factors,the current in the clinical treatment and prognosis also no significant differences. |
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