| Objective:Retrospective analysis of the features of general clinical data, postoperative treatment and follow-up of the patients with gastric cancer who accepted the gastric cancer radical surgery. We analyzed the correlation of the general clinical data, postoperative treatment and survival of the patients. Moreover, the expression of VEGF-A and VEGF-D in the cancer and para-carcinoma tissues of gastric cancer were determined by the immunohistochemical technology, and then the correlation of the expression of VEGF-A and VEGF-D and the general clinical data, postoperative treatment and survival of the patients. At the last time, we revealed the VEGF-A, VEGF-D factors play A role in gastric cancer development.Methods:Retrospective analysis of the gastric cancer patients who received radical operation and had complete follow-up information in Hospital from May 2013 to July 2015 and statistical analysis the correlation of the general clinical data, postoperative treatment and survival. We detected the expression of VEGF-A, D by immunohistochemistry. We analyzed the relationship of the above VEGF-A, D expression and features of clinicopathology and survival of the gastric cancer patients after radical operation with the statistic software version 13.0.Results:1. Results showed that surgical margin, tumor size, depth of invasion, lymph node metastasis, Borrmann type, WHO histological classification, Lauren points type, TNM classification, adjuvant chemotherapy cycle were the risk factors of DFS in patients post-operation. Moreover, surgical margin, depth of invasion, lymph node metastasis, Borrmann type, WHO histological classification, Lauren points type, TNM classification, adjuvant chemotherapy cycle were the risk factors of OS.2. It showed that surgical margin, Borrmann type, TNM stage were independent prognostic factors in medial DFS and Borrmann type, TNM stage were independent prognostic factors in medial OS.3. The over expression rate of VEGF-A in the tissues of gastric cancer was significantly higher than that in non-cancerous adjacent gastric tissue. There was significant correlation between the expression of VEGF-A and tumour location, namely to the expression of VEGF-A mainly concentrated in the upper stomach.4. The results of single factor analysis of the expression of VEGF-A and medial DFS, medial OS showed that the medial DFS, medial OS in patients with lower expression of VEGF-A longer than the higher expression of VEGF-A.5. The over expression rate of VEGF-D in the tissues of gastric cancer was significantly higher than that in non-cancerous adjacent gastric tissue. The expression of VEGF-D same as VEGF-A mostly, but the expression of VEGF-D concentrated in the lower part of the stomach in contrast to the VEGF-A.6. The results of single factor analysis of the expression of VEGF-D and medial DFS, medial OS showed that the medial DFS, medial OS in patients with lower expression of VEGF-D longer than the higher expression of VEGF-D.7. The spearman rank correlation analysis results showed that there was a certain correlation between the expression of VEGF-Aand VEGF-D.Conclusions:Surgical margin, Borrmann type and TNM stage were the independent prognostic factors of medial DFS. Borrmann type and TNM stage were the independent prognostic factors of medial OS. The over expression rate of VEGF-A and VEGF-D in gastric cancer tissues and were expected to become the diagnosis of gastric cancer prognosis factors. |
