Clinical Research Of Tadalafil For The Treatment Of ED After Fpkrp

Objective: To evaluate the efficacv and safety of tadalafil taken once daily in treatment of ED and lower urinary tract symptoms after four area division plasmakinetic enucleation of prostate.Methods: 58 cases of postoperative FPKRP ED patients were assigned into experimental group and control group according to their wishes,experimental group received 12 weeks of tadalafil 5 mg once a day treatment,and the control group were banned on the use of PDE5 inhibitor drugs. Before and after the treatment, and after 6 months of follow-up, two groups of patients were recorded in patients with international index of erectile function-5(IIEF-5) score and penile erectile angle, diary of sex life(SEP) 2(sep-2, whether can successfully inserted into the vagina?) and 3(sep-3, whether can maintain a sufficient length of time to complete the sexual intercourse?), International Prostate Symptom Score(IPSS),quality of life score(QOL), maximum flow rate(Qmax) and prostate specific angitite(PSA) were compared with before and after the treatment. Results: In the experimental group, 29 cases were markedly effective in 12 cases,effective in 13 cases, and ineffective in 4 cases,the total effective rate reach 86.2%,compared with the control group, the difference was statistically significant(Z=-3.421,P=0.001);a good curative effect can be maintained at the time of follow-up after six months, 29 cases were markedly effective in 9 cases, effective in 17 cases, and ineffec- tive in 3 cases,the total effective rate reach 89.65%,compared with the control group, the difference was statistically significant(Z=-2.795, P=0.005).After the end of the treatment and at 6 months follow-up time,the general IIEF-5(19.62±2.94,19.55±1.82), IPSS(8.14±1.94,9.21±1.72), QOL(1.93±0.75,2.03±0.57) and Qmax(16.34±2.34,16.35±2.15)were significantly changed compared with before and the control group, and the difference were statistically significant(P< 0.05);after the end of the treatment and at 6 months follow-up time,the general PSA(3.81±0.83,3.75±0.71) had no statistical significance compared with before and the control group(P>0.05). Conclusions: Tadalafil has a better therapeutic effect and safety for the treatment of ED after FPKRP, and it can also improve LUTS symptoms, it is suitable to be recommended as a first-line therapy for patients with ED after BPH surgery.